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Chemical Compound Review

AGN-PC-00K2VF     2-[3-acetamido-2,5-dihydroxy- 6...

Synonyms: SureCN13575286, AC1LBU2X, 61633-75-8, N-acetylmuramic acid, N-ACETYL ALPHA-MURAMIC ACID
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Disease relevance of N-acetylmuramate


High impact information on N-acetylmuramate

  • In this study we show that human MBL, but not serum amyloid component P, binds significantly to PGN via its C-type lectin domains, and that the interaction can be more effectively competed by GlcNAc than by MurNAc [2].
  • A murQ deletion mutant could not grow on MurNAc as the sole source of carbon and energy but could be complemented by expressing murQ from a plasmid [1].
  • The mutant had no obvious phenotype when grown on different carbon sources but accumulated MurNAc 6-phosphate at millimolar concentrations from externally supplied MurNAc [1].
  • We report that human PGRP-L is a Zn2+-dependent N-acetylmuramoyl-l-alanine amidase (EC, an enzyme that hydrolyzes the amide bond between MurNAc and l-Ala of bacterial PGN [3].
  • Close homologs of MurP were identified in the genome of several bacteria, and we believe that these organisms might also be able to utilize MurNAc [4].

Chemical compound and disease context of N-acetylmuramate


Associations of N-acetylmuramate with other chemical compounds


  1. Scission of the lactyl ether bond of N-acetylmuramic acid by Escherichia coli "etherase". Jaeger, T., Arsic, M., Mayer, C. J. Biol. Chem. (2005) [Pubmed]
  2. Mannose-binding lectin recognizes peptidoglycan via the N-acetyl glucosamine moiety, and inhibits ligand-induced proinflammatory effect and promotes chemokine production by macrophages. Nadesalingam, J., Dodds, A.W., Reid, K.B., Palaniyar, N. J. Immunol. (2005) [Pubmed]
  3. Human peptidoglycan recognition protein-L is an N-acetylmuramoyl-L-alanine amidase. Wang, Z.M., Li, X., Cocklin, R.R., Wang, M., Wang, M., Fukase, K., Inamura, S., Kusumoto, S., Gupta, D., Dziarski, R. J. Biol. Chem. (2003) [Pubmed]
  4. Identification of a phosphotransferase system of Escherichia coli required for growth on N-acetylmuramic acid. Dahl, U., Jaeger, T., Nguyen, B.T., Sattler, J.M., Mayer, C. J. Bacteriol. (2004) [Pubmed]
  5. Conserved sequences in enzymes of the UDP-GlcNAc/MurNAc family are essential in hamster UDP-GlcNAc:dolichol-P GlcNAc-1-P transferase. Dal Nogare, A.R., Dan, N., Lehrman, M.A. Glycobiology (1998) [Pubmed]
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