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Chemical Compound Review:

CPD-1786 2-(4-chlorophenyl)ethanoate

Synonyms: AG-A-74499, CHEBI:16237, AC1NUT5M, CTK5I4980, ZINC00156077, ...

This record was replaced with 15880.

Sawatsri, S. et al., Markus, A. et al., Schweizer, D. et al.

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Disease relevance of NSC 14285

Purification and some properties of component B of the 4-chlorophenylacetate 3,4-dioxygenase from Pseudomonas species strain CBS 3 [1].
We have determined that PA and its halide derivative 4-chlorophenylacetate (4-CPA) showed marked antiproliferative activity on 3 of 6 human breast cancer cell lines tested [2].

High impact information on NSC 14285

In cell-free extracts from Pseudomonas sp. strain CBS3 the conversion of 4-chlorophenylacetate to 3,4-dihydroxyphenylacetate was demonstrated [3].

References

Purification and some properties of component B of the 4-chlorophenylacetate 3,4-dioxygenase from Pseudomonas species strain CBS 3. Schweizer, D., Markus, A., Seez, M., Ruf, H.H., Lingens, F. J. Biol. Chem. (1987) [Pubmed]
Inhibition of estrogen-dependent breast cell responses with phenylacetate. Sawatsri, S., Samid, D., Malkapuram, S., Sidell, N. Int. J. Cancer (2001) [Pubmed]
Oxidation and dehalogenation of 4-chlorophenylacetate by a two-component enzyme system from Pseudomonas sp. strain CBS3. Markus, A., Klages, U., Krauss, S., Lingens, F. J. Bacteriol. (1984) [Pubmed]

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