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Chemical Compound Review

M-Ibdet     1,1-diethyl-3-[(1-methyl-2- oxo-indol-3...

Synonyms: AC1NUYWT
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Disease relevance of M-Ibdet

  • These results suggest that the inhibition of Moloney leukemia virus by M-IBDET involves a block in the translation of viral RNA rather than interference with viral RNA transcription [1].
  • A significant selective inhibition of HIV structural protein synthesis was shown by both M-IBDET and A-IBDAT [2].

High impact information on M-Ibdet

  • An examination of the effect of M-IBDET on polysomes engaged in the translation of viral proteins revealed a fourfold accumulation of polysomal virus-specific RNA in drug-treated cells [1].
  • N-Methylisatin-beta-4':4'-diethylthiosemicarbazone (M-IBDET) inhibits intracellular production of viral constituents in a mouse cell line, 3T3/MLV, chronically infected with Moloney leukemia virus [3].


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