Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

AC1NUP00 3-[[(1S)-1-[[(2S)-1-[(2S)-2- [[(2S)-2-[(4...

Synonyms: Suc-ala-ala-pro-phe-4-NA

Roberts, I.N. et al., Kakalis, L.T. et al., Cookson, A.L. et al., Zhu, L. et al.

Roberts, Passeron, Barneix,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Suc-aapf-pna

In order to gain insights into the PPIase mechanism, transferred nuclear Overhauser effect (TRNOE) measurements by two-dimensional 1H NMR were used to determine the conformation of the isomerase-bound standard model substrate suc-AAPF-pNA [1].
According to its biochemical and physical properties (inhibition by chymostatin and PMSF, broad pH range of activity, thermostability and ability to hydrolyse Suc-AAPF-pNA) P2 was classified as a serine protease with chymotrypsin-like activity [2].
37.5% (3 of 8) of P. intermedia strains hydrolysed SAAPPNA (chymotrypsin-like enzyme activity) with activities of between 7 and 12 units [3].
The optimum pH range was 7.5-9.5 for suc-AAPF-pNA substrate and was 10-12 for casein substrate [4].

References

Solution conformation of a cyclophilin-bound proline isomerase substrate. Kakalis, L.T., Armitage, I.M. Biochemistry (1994) [Pubmed]
The two main endoproteases present in dark-induced senescent wheat leaves are distinct subtilisin-like proteases. Roberts, I.N., Passeron, S., Barneix, A.J. Planta (2006) [Pubmed]
An investigation into the use of SDS-PAGE of cell surface extracts and proteolytic activity to differentiate Prevotella nigrescens and Prevotella intermedia. Cookson, A.L., Wray, A., Handley, P.S., Jacob, A.E. FEMS Microbiol. Lett. (1996) [Pubmed]
Protein engineering on subtilisin E. Zhu, L., Ji, Y. Chin. J. Biotechnol. (1997) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

Editor

Share