Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

CHEMBL83597 3-[[(2R)-1-methylpyrrolidin- 2-yl]methyl]-N...

Synonyms: SureCN7851221, CHEBI:234577, AC1NUP43, CP-135807, LS-183377, ...

Mansbach, R.S. et al., Stenfors, C. et al., Rollema, H. et al.

Stenfors, Hallerbäck, Larsson, Wallsten, Ross,

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Disease relevance of CP 135807

AR-A000002 also blocked 5-HT(1B) agonist-induced (CP-135,807) decrease in 5-HT metabolism and hypothermia (ED(50)=1 mg/kg s.c.), thus indicating competition between these two drugs [1].

High impact information on CP 135807

Moreover, at these doses GR127935 significantly attenuated the decrease in extracellular 5-HT levels following local perfusion with the selective 5-HT1D agonist CP-135,807 [2].
CP-135,807, a selective 5-HT1D agonist: effects in drug discrimination and punishment procedures in the pigeon [3].
Collectively, these results suggest that CP-135,807 produces centrally mediated psychoactive effects that differ distinctly from those of 5-HT1A agonists [3].

References

Pharmacology of a novel selective 5-hydroxytryptamine1B receptor antagonist, AR-A000002. Stenfors, C., Hallerbäck, T., Larsson, L.G., Wallsten, C., Ross, S.B. Naunyn Schmiedebergs Arch. Pharmacol. (2004) [Pubmed]
Combined administration of a 5-hydroxytryptamine (5-HT)1D antagonist and a 5-HT reuptake inhibitor synergistically increases 5-HT release in guinea pig hypothalamus in vivo. Rollema, H., Clarke, T., Sprouse, J.S., Schulz, D.W. J. Neurochem. (1996) [Pubmed]
CP-135,807, a selective 5-HT1D agonist: effects in drug discrimination and punishment procedures in the pigeon. Mansbach, R.S., Rovetti, C.C., Macor, J.E. Psychopharmacology (Berl.) (1996) [Pubmed]

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