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Chemical Compound Review:

DONV (Z,4S)-4-amino-4-carboxy-1- diazonio-but-1...

Synonyms: L-Donv, AC1NUQDX, LS-97522, NSC 117613, C5H7N3O3, ...

This record was replaced with 6913179.

Chang, P.K. et al., Lachman, L.B. et al., Mesas, J.M. et al.

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Disease relevance of

Earlier work has shown that 5-diazo-4-oxo-L-norvaline (DONV) irreversibly inactivates the L-asparaginase from E. coli by formation of a covalent bond in the region of the active site [1].

High impact information on

The active site of L-asparaginase: dimethylsulfoxide effect of 5-diazo-4-oxo-L-norvaline interactions [2].
The L-asparaginase activity was inhibited by the L-asparagine analogue 5-diazo-4-oxo-L-norvaline [3].

References

Synthesis of model compounds relevant to the active-site-directed inactivation of L-asparaginase by 5-diazo-4-oxo-L-norvaline. Chang, P.K., Lachman, L.B., Handschumacher, R.E. Int. J. Pept. Protein Res. (1979) [Pubmed]
The active site of L-asparaginase: dimethylsulfoxide effect of 5-diazo-4-oxo-L-norvaline interactions. Lachman, L.B., Handschumacher, R.E. Biochem. Biophys. Res. Commun. (1976) [Pubmed]
Characterization and partial purification of L-asparaginase from Corynebacterium glutamicum. Mesas, J.M., Gil, J.A., Martín, J.F. J. Gen. Microbiol. (1990) [Pubmed]

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