Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

HGP-5 (NE)-N-[1-(propan-2-ylamino)- 3-(2-prop-2...

Synonyms: CDDD-1815, CHEMBL2105963, AC1NUR8J, L003903, ALPRENOXIME HYDROCHLORIDE

Bodor, N. et al., Polgar, P. et al.

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Disease relevance of Alprenoxime

Both in rats and in rabbits the i.v. bolus injection of AO (6 mg/kg) led to insignificant transient bradycardia, while no activity was found after oral or topical administration [1].

High impact information on Alprenoxime

The effect of this compound, alprenoxime (AO), on the intraocular pressure (IOP) of rabbits was evaluated after its uni- and bilateral administration [1].
Previous studies in rabbits confirmed that intraocular pressure (IOP) significantly decreased after topically instilling ophthalmic drops of alprenoxime, while heart rates remained essentially unchanged after intravenous dosing [2].

Analytical, diagnostic and therapeutic context of Alprenoxime

AO produced significant reduction of the IOP starting at 30 min and lasting for more than 6 hr after its topical administration [1].

References

Improved delivery through biological membranes. LVI. Pharmacological evaluation of alprenoxime--a new potential antiglaucoma agent. Bodor, N., Elkoussi, A. Pharm. Res. (1991) [Pubmed]
Minimal cardiac electrophysiological activity of alprenoxime, a site-activated ocular beta-blocker, in dogs. Polgar, P., Bodor, N. Life Sci. (1995) [Pubmed]

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