Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

Leucokinin I (3S)-3-amino-4-[(2S)-2- [[(1S)-1-[[(1S)-1...

Synonyms: Leukokinin I, AC1NUS5K, C15927, 104600-89-7, Asp-pro-ala-phe-asn-ser-trp-gly-NH2

Lundquist, C.T. et al., Iaboni, A. et al., Cantera, R. et al., Schmid, A. et al., Elekes, K. et al., et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Leukokinin I

Peptidergic neurons in the snail Helix pomatia: distribution of neurons in the central and peripheral nervous systems that react with an antibody raised to the insect neuropeptide, leucokinin I [1].
Additionally, Anopheles leucokinin I displays sequence similarity to Drosophila melanogaster leucokinin [2].
Only two of the peptides, [Leu(5)]enkephalinamide and leucokinin-I were cleaved faster by Acer [3].
The distribution of a CRF-related diuretic peptide (Musca-DP) and the diuretic/myotropic insect myokinins in the central nervous system of larval and adult houseflies was investigated using antisera raised against Locusta-DH and leucokinin-I, respectively [4].
A specific antiserum immunoreactive to the neuroactive octapeptide leucokinin I (LKI) has been used to map neurones within the central nervous system of the central American wandering spider Cupiennius salei [5].

Anatomical context of Leukokinin I

In the abdominal ganglia of the turnip moth Agrotis segetum, an antibody against the cockroach neuropeptide leucokinin I recognizes neurons with varicose fibers and terminals innervating the perisympathetic neurohemal organs [6].

Analytical, diagnostic and therapeutic context of Leukokinin I

A competitive ELISA employing a polyclonal antiserum raised against leucokinin-I was used to isolate and purify a myokinin (muscakinin) from 1.05 kg of adult houseflies (Musca domestica) [7].
In radioimmunoassays (with antisera against kassinin and leucokinin I) used in combination with reverse-phase HPLC, it was shown that the antisera recognize immunoreactive material with distinctly hydrophobic properties and each antiserum appear to detect several forms of immunochemically related peptides [8].

References

Peptidergic neurons in the snail Helix pomatia: distribution of neurons in the central and peripheral nervous systems that react with an antibody raised to the insect neuropeptide, leucokinin I. Elekes, K., Hernádi, L., Muren, J.E., Nässel, D.R. J. Comp. Neurol. (1994) [Pubmed]
Functional characterisation of the Anopheles leucokinins and their cognate G-protein coupled receptor. Radford, J.C., Terhzaz, S., Cabrero, P., Davies, S.A., Dow, J.A. J. Exp. Biol. (2004) [Pubmed]
Peptidyl dipeptidases (Ance and Acer) of Drosophila melanogaster: major differences in the substrate specificity of two homologs of human angiotensin I-converting enzyme. Siviter, R.J., Nachman, R.J., Dani, M.P., Keen, J.N., Shirras, A.D., Isaac, R.E. Peptides (2002) [Pubmed]
Immunocytochemical localisation and biological activity of diuretic peptides in the housefly, Musca domestica. Iaboni, A., Holman, G.M., Nachman, R.J., Orchard, I., Coast, G.M. Cell Tissue Res. (1998) [Pubmed]
Leucokinin-like immunoreactive neurones in the central nervous system of the spider Cupiennius salei. Schmid, A., Becherer, C. Cell Tissue Res. (1996) [Pubmed]
Postembryonic development of leucokinin I-immunoreactive neurons innervating a neurohemal organ in the turnip moth Agrotis segetum. Cantera, R., Hansson, B.S., Hallberg, E., Nässel, D.R. Cell Tissue Res. (1992) [Pubmed]
Isolation, characterization and biological activity of a diuretic myokinin neuropeptide from the housefly, Musca domestica. Holman, G.M., Nachman, R.J., Coast, G.M. Peptides (1999) [Pubmed]
Tachykinin- and leucokinin-related peptides in the nervous system of the blowfly: immunocytochemical and chromatographical diversity. Lundquist, C.T., Brodin, E., Muren, J.E., Nässel, D.R. Peptides (1993) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.