Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Nebicin 4-amino-2-[4,6-diamino-3-[3- amino-6...

Synonyms: Distobram, Obracin, Obramycin, Brulamycin, tobramycin, ...

Byrne, M.E. et al., Laverdière, M. et al.

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Disease relevance of Obracin

Plasmid-encoded resistance to the aminoglycosides gentamicin (Gm), tobramycin (Tm), and kanamycin (Km) (GmTmKmr) in strains of Staphylococcus aureus isolated in Australia and North America appears to be mediated by one resistance determinant [1].

High impact information on Obracin

Checkerboard studies revealed striking synergy (FIC indices < or = 0.5) for CEF, however, in combination with either TOB (72%) or NET (81%), compared with CAZ-TOB (44%) or CAZ-NET (60%) (P < 0.01, respectively) [2].

References

Molecular analysis of a gentamicin resistance transposonlike element on plasmids isolated from North American Staphylococcus aureus strains. Byrne, M.E., Gillespie, M.T., Skurray, R.A. Antimicrob. Agents Chemother. (1990) [Pubmed]
In vitro synergism of ceftriaxone combined with aminoglycosides against Pseudomonas aeruginosa. Laverdière, M., Gallimore, B., Restieri, C., Poonia, K., Chow, A.W. Diagn. Microbiol. Infect. Dis. (1994) [Pubmed]

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