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Chemical Compound Review

Adaferin     6-[3-(1-adamantyl)-4- methoxy...

Synonyms: Adapalen, Differin, ADAPALENE, Adapaleno, Differine, ...
 
 
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Disease relevance of CD 271

 

High impact information on CD 271

  • From series I, a mixed RAR beta-gamma agonist with potent cellular differentiating activity was selected for development as a topical antiacne agent, 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid (5, CD 271) [Ki(RAR alpha) = 1100 nM, Ki-(RAR beta) = 34 nM, Ki(RAR gamma) = 130 nM, AC50(F9) = 37 nM] [4].
  • The purpose of this meta-analysis was to determine if adapalene 0.1% gel (Differin) provided superior efficacy and better tolerability than tretinoin 0.025% gel in the treatment of acne vulgaris [5].
  • No CD 271 could be detected in blood plasma at the end of the study (detection limit = 1 ng/ml) [6].

References

  1. A selective retinoid with high activity against an androgen-resistant prostate cancer cell type. Lu, X.P., Fanjul, A., Picard, N., Shroot, B., Pfahl, M. Int. J. Cancer (1999) [Pubmed]
  2. Recent developments in receptor-selective retinoids. Nagpal, S., Chandraratna, R.A. Curr. Pharm. Des. (2000) [Pubmed]
  3. Skin tolerance of adapalene 0.1% gel in combination with other topical antiacne treatments. Caron, D., Sorba, V., Clucas, A., Verschoore, M. J. Am. Acad. Dermatol. (1997) [Pubmed]
  4. Synthesis, structure-affinity relationships, and biological activities of ligands binding to retinoic acid receptor subtypes. Charpentier, B., Bernardon, J.M., Eustache, J., Millois, C., Martin, B., Michel, S., Shroot, B. J. Med. Chem. (1995) [Pubmed]
  5. A comparison of the efficacy and tolerability of adapalene 0.1% gel versus tretinoin 0.025% gel in patients with acne vulgaris: a meta-analysis of five randomized trials. Cunliffe, W.J., Poncet, M., Loesche, C., Verschoore, M. Br. J. Dermatol. (1998) [Pubmed]
  6. Efficacy and safety of CD 271 alcoholic gels in the topical treatment of acne vulgaris. Verschoore, M., Langner, A., Wolska, H., Jablonska, S., Czernielewski, J., Schaefer, H. Br. J. Dermatol. (1991) [Pubmed]
 
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