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Chemical Compound Review:

SureCN40830 2-[(2-amino-6-oxo-3H-purin- 9...

Synonyms: CHEMBL1201110, CCG-100889, NSC-759101, AC-11593, KB-62215, ...

This record was replaced with 60773.

Katragadda, S. et al., Anand, B.S. et al., Sra, K.K. et al., Dhaliwal, D.K. et al., Dhaliwal, D.K. et al., et al.

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Disease relevance of Acyclovir-valine

Valaciclovir (Valtrex) 2 g twice daily for 1 day was recently approved in the United States for treatment of cold sores [1].
CONCLUSIONS: The prophylactic administration of Valtrex reduced EBV reactivation but was not an effective intervention strategy for limiting upper respiratory symptoms in this cohort of elite distance runners [2].
PURPOSE: To determine whether the systemic administration of valacyclovir (Valtrex) reduces ocular shedding of herpes simplex virus type 1 (HSV-1) after laser in situ keratomileusis (LASIK) in the New Zealand White (NZW) rabbit latency model [3].
PURPOSE: The goal of this was to determine whether the systemic administration of valacyclovir (Valtrex) would reduce ocular shedding of herpes simplex virus 1 (HSV-1) after excimer laser ablation in the New Zealand rabbit latency model [4].
Acyclovir (Zoviraxr, GlaxoSmithKline), valacyclovir (Valtrex, GlaxoSmithKline) or famciclovir (Famvir, Novartis) can be used to treat herpes zoster, and all three have been shown to reduce the duration of the herpetic rash and zoster-associated pain [5].

High impact information on Acyclovir-valine

Our results suggest the possibility that antibodies directed against this fibroblast antigen may be related to the developm[6]
Enhanced bioavailability of VACV has been attributed to its carrier-mediated intestinal absorption via hPEPT1 peptide transporter followed by rapid and complete conversion to ACV [7].
The principle enzyme classes responsible for the hydrolysis of VACV and GVACV were carboxylesterases and aminopeptidases respectively [8].
Eserine, tetraethyl pyrophosphate (TEPP) and diisopropyl fluorophosphate (DFP) also produced significant inhibition of VACV hydrolysis [8].
The panel members discussed the use of valacyclovir (Valtrex) to provide prophylaxis for herpes zoster, trimethoprim/sulfamethoxazole for Pneumocystis, and acyclovir (Zovirax) for varicella zoster [9].

Biological context of Acyclovir-valine

Interestingly, the bioavailability of ACV after administration of GVACV was approximately 2-fold higher than VACV [7].

Anatomical context of Acyclovir-valine

Transport studies were conducted with isolated rabbit corneas at 34 degrees C. Complete inhibition of VACV hydrolysis was observed in the presence of Pefabloc SC (4-(2-aminoethyl)-benzenesulfonyl-fluoride) and PCMB (p-chloromercuribenzoic acid) [8].

Analytical, diagnostic and therapeutic context of Acyclovir-valine

Systemic availability of ACV in humans is 3 to 5 times higher after oral administration of VACV [7].
By the way, doctor. My 47-year-old son suddenly lost hearing in one ear. They did some blood tests and he was given steroids and a medication called Valtrex. Now they are saying nothing can be done. Can you please address this issue [10]?

References

Clinical significance of antiviral therapy for episodic treatment of herpes labialis: exploratory analyses of the combined data from two valaciclovir trials. Spruance, S.L., Hill, J. J. Antimicrob. Chemother. (2004) [Pubmed]
Valtrex therapy for Epstein-Barr virus reactivation and upper respiratory symptoms in elite runners. Cox, A.J., Gleeson, M., Pyne, D.B., Saunders, P.U., Clancy, R.L., Fricker, P.A. Medicine and science in sports and exercise. (2004) [Pubmed]
Valacyclovir inhibition of recovery of ocular herpes simplex virus type 1 after experimental reactivation by laser in situ keratomileusis. Dhaliwal, D.K., Romanowski, E.G., Yates, K.A., Hu, D., Mah, F.S., Fish, D.N., Gordon, Y.J. Journal of cataract and refractive surgery. (2001) [Pubmed]
Valacyclovir inhibits recovery of ocular HSV-1 after experimental reactivation by excimer laser keratectomy. Dhaliwal, D.K., Romanowski, E.G., Yates, K.A., Barnhorst, D.A., Goldstein, M., Deeter, R.G., Fish, D.N., Gordon, Y.J. Cornea (1999) [Pubmed]
Treatment of postherpetic neuralgia. Sra, K.K., Tyring, S.K. Skin Therapy Lett. (2004) [Pubmed]
Presence of antibodies in the sera of patients with Graves' disease recognizing a 23 kilodalton fibroblast protein. Bahn, R.S., Gorman, C.A., Johnson, C.M., Smith, T.J. J. Clin. Endocrinol. Metab. (1989) [Pubmed]
Pharmacokinetics of novel dipeptide ester prodrugs of acyclovir after oral administration: intestinal absorption and liver metabolism. Anand, B.S., Katragadda, S., Mitra, A.K. J. Pharmacol. Exp. Ther. (2004) [Pubmed]
Simultaneous modulation of transport and metabolism of acyclovir prodrugs across rabbit cornea: An approach involving enzyme inhibitors. Katragadda, S., Talluri, R.S., Mitra, A.K. International journal of pharmaceutics. (2006) [Pubmed]
Infectious complications of pentostatin therapy. Vose, J.M., Cabanillas, F., O'Brien, S., Dang, N., Drapkin, R., Foss, F. Oncology (Williston Park, N.Y.) (2000) [Pubmed]
By the way, doctor. My 47-year-old son suddenly lost hearing in one ear. They did some blood tests and he was given steroids and a medication called Valtrex. Now they are saying nothing can be done. Can you please address this issue? Gopen, Q.S. Harvard health letter / from Harvard Medical School (2007) [Pubmed]

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