Disease relevance of phenoxybenzamine

• The fact no inhibition of ADP effects could be demonstrated with dibenzyline and hexamethonium, which also produced marked hypotension of long duration, indicated that inhibition of the ADP effect by the four antagonists studied was not due to changes in blood pressure [1].
• Phenoxybenzamine (Dibenzyline) has been extremely effective in treating patients with detrusor dyssynergia [2].
• A case is presented of a 58-year old man with a 20-year history of malignant pheochromocytoma well controlled on Dibenzyline who was found to have poorly differentiated lymphocytic lymphoma [3].
• It seems from this clinical trial that prophylactic treatment with Dibenzyline is recommended after abdominal hysterectomy or vaginal operation in order to improve micturition and prevent urinary retention [4].
• The effects of "M"-receptor blockers (atropine and morphine), "D"-receptor blockers (dibenamine, dibenzyline, methysergide) and a ganglion blocking agent (mecamylamine) were studied to characterize cardiovascular tryptaminergic receptors in domestic fowl [5].

High impact information on phenoxybenzamine

• Thirty-three years ago, Gaddum and Picarelli classified the serotonin receptors in the guinea pig ileum into D and M types based on the activity of dibenzyline (D) and morphine (M) to block contractions of intestinal smooth muscle caused by serotonin [6].
• Thirty-three years ago, Gaddum and Picarelli classified the serotonin receptors in the guinea pig ileum into D and M types based on the activity of dibenzyline and morphine to block contractions of intestinal smooth muscle caused by serotonin [7].
• Spinal cord blood flow (SCBF) was measured over a wide range of artificially varied mean systemic arterial blood pressures (MAP) in a group of monkeys with alpha adrenergic receptors blocked by the intravenous administration of phenoxybenzamine (Dibenzyline) [8].
• On the basis of this hypothesis, fetal cardiovascular responses to partial occlusion of the umbilical cord or isolated intra-abdominal portion of umbilical vein were studied in near-term pregnant baboons and rhesus monkeys prior to and following sympathetic blockade with dibenzyline and propranolol [9].
• Norepinephrine and transmural electrical stimulation contracted the ductus sphincter in vitro, and their action was abolished by dibenzyline [10].

Anatomical context of phenoxybenzamine

• Using the guinea-pig isolated ileum, Gaddum and Picarelli (1957) suggested that 5-HT-induced contractions were mediated by a morphine-sensitive "M" receptor located on the parasympathetic ganglion and a dibenzyline-sensitive "D" receptor located on the smooth muscle [11].

Associations of phenoxybenzamine with other chemical compounds

• Pretreatment with allopurinol, dibenzyline, methylprednisolone, glucagon, ATP-MgCl2 and aspartic acid reduced the overall mortality of ischemic liver injury [12].

Analytical, diagnostic and therapeutic context of phenoxybenzamine

• The lever-pressing rate for brain stimulation decreased under the effect of both dibenzyline, an adrenergic blocking agent, and local anesthesia of the cervical vago-sympathetic trunk by procaine [13].
• In a randomized clinical trial, 51 patients who underwent total abdominal hysterectomy, received a prophylactic dose of Dibenzyline 10 micrograms orally 6-8 hours after operation and again the next day about 18 hours later [4].
• Addition of an alpha-blocking agent (dibenzyline to the denervated muscle unmasked the constriction, but the percent of arterioles demonstrating thermal reactivity remained decreased [14].
• Measurements were repeated following extensive ligation of veins and after subsequent alpha-receptor blockade with Dibenzyline [15].
• Nine pigs underwent hepatectomy without pretreatment, while six were given 2 milligrams per kilogram of Dibenzyline prior to hepatic dissection [16].

References