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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

RADON-222     radon

Synonyms: CHEBI:33492, LS-143268, AC1L1VW4, C16454, (222)Rn, ...
 
 
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Disease relevance of radon

  • Two possibilities have been explored here to explain the apparent discrepancy between predicted and observed bronchial tumors: (1) Bronchial doses are smaller than presently predicted; and/or (2) lung cancer risk per unit exposure in Thorotrast patients is smaller than that derived from inhalation of (222)Rn progeny [1].
 

High impact information on radon

  • In an effort to mimic human in vivo exposures to ionizing irradiation, G(0) phase T lymphocytes from human peripheral blood samples were utilized for in vitro studies of the genotoxic effects of (137)Cs low-LET irradiation and (222)Rn high-LET irradiation [2].
  • Both types of radiation induced mutations in the HPRT gene in a dose-dependent manner, with a mutant frequency (MF) = 4.28 + 1.34x + 7.51x(2) for (137)Cs (R(2) = 0.95) and MF = 4.81 + 0.67x for (222)Rn (R(2) = 0.51) [2].
  • The hot springs in certain areas of Ramsar contain (226)Ra and (222)Rn [3].
  • The partial sensitivity rho(i) of the LR 115 detector applied in the bare mode to (222)Rn and its short-lived progeny is related to the equilibrium factor F through the proxy equilibrium factor F(p) [4].
  • The associated health risk for employees and patients due to the inhalation of (222)Rn and its progeny was estimated [5].
 

Biological context of radon

  • Seasonal variations in (222)Rn concentrations at offices, schools and hospitals were similar to those found in dwellings, and variations in factories were similar to those found in outdoor environments [6].
  • The accumulation method, by using the E-PERM electret ion chambers, was employed to determine specific exhalation rates of (222)Rn [7].
  • The (222)Rn concentrations in seawater varied from 2.3kBqm(-3) during high tides to 4.8kBqm(-3) during low tides, thus confirming an influence of the tide on submarine groundwater discharge [8].
  • Contribution of (222)Rn-bearing water to the occupational exposure in thermal baths [9].
 

Associations of radon with other chemical compounds

  • Comprehensive understanding of (222)Rn exhalation from phosphogypsum-bearing building material and its accumulation in indoor air is likely to rely on numerical simulation, particularly if transient effects, three-dimensional domains and convection are to be included and investigated [10].
 

Analytical, diagnostic and therapeutic context of radon

References

  1. Lung dosimetry for thorotrast patients: implications for inhalation of radon progeny. Hofmann, W., Hornik, S. Radiat. Res. (1999) [Pubmed]
  2. In vitro studies of the genotoxicity of ionizing radiation in human G(0) T lymphocytes. O'Neill, P., Nicklas, J., Hirsch, B., Jostes, R., Hunter, T., Sullivan, L., Albertini, R. Environ. Mol. Mutagen. (2005) [Pubmed]
  3. Adaptive response of blood lymphocytes of inhabitants residing in high background radiation areas of ramsar- micronuclei, apoptosis and comet assays. Mohammadi, S., Taghavi-Dehaghani, M., Gharaati, M.R., Masoomi, R., Ghiassi-Nejad, M. J. Radiat. Res. (2006) [Pubmed]
  4. Derivation of V function for LR 115 SSNTD from its partial sensitivity to (222)Rn and its short-lived progeny. Leung, S.Y., Nikezic, D., Yu, K.N. Journal of environmental radioactivity (2007) [Pubmed]
  5. Estimation of the radiological risk related to the presence of radon 222 in a hydrotherapy centre in Tunisia. Labidi, S., Essafi, F., Mahjoubi, H. Journal of radiological protection : official journal of the Society for Radiological Protection. (2006) [Pubmed]
  6. A survey of indoor workplace radon concentration in Japan. Oikawa, S., Kanno, N., Sanada, T., Abukawa, J., Higuchi, H. Journal of environmental radioactivity. (2006) [Pubmed]
  7. Natural radioactivity and radon exhalation in building materials used in Italian dwellings. Righi, S., Bruzzi, L. Journal of environmental radioactivity. (2006) [Pubmed]
  8. Characterisation of submarine groundwater discharge offshore south-eastern Sicily. Povinec, P.P., Aggarwal, P.K., Aureli, A., Burnett, W.C., Kontar, E.A., Kulkarni, K.M., Moore, W.S., Rajar, R., Taniguchi, M., Comanducci, J.F., Cusimano, G., Dulaiova, H., Gatto, L., Groening, M., Hauser, S., Levy-Palomo, I., Oregioni, B., Ozorovich, Y.R., Privitera, A.M., Schiavo, M.A. Journal of environmental radioactivity. (2006) [Pubmed]
  9. Contribution of (222)Rn-bearing water to the occupational exposure in thermal baths. Vogiannis, E., Niaounakis, M., Halvadakis, C.P. Environment international. (2004) [Pubmed]
  10. Radon exhalation from phosphogypsum building boards: symmetry constraints, impermeable boundary conditions and numerical simulation of a test case. Rabi, J.A., da Silva, N.C. Journal of environmental radioactivity. (2006) [Pubmed]
  11. Natural radioactivity in tap waters of Eastern Black Sea region of Turkey. Cevik, U., Damla, N., Karahan, G., Celebi, N., Kobya, A.I. Radiation protection dosimetry. (2006) [Pubmed]
 
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