High impact information on alpha-Naphthylaldehyde

• The naphthaldehyde hydroxyl, ortho to the HNA-P aldehyde, was essential for promoting carbinolamine precursor formation by intramolecular catalysis [1].
• The kinetics of proton uptake/release during naphthaldehyde reduction at pH 6 are shown to be consistent with the proposed mechanism of enzyme action [2].
• Among the tested compounds, naphthaldehyde 1 showed moderate inhibition of the growth of the parasites, T. brucei, T. cruzi, L. donovani with IC(50) values of 19.82, 12.28 and 38.78muM and displayed cytotoxicity towards rat skeletal myoblasts (L-6 cells) with IC(50) of 174.94muM, while 2 and 3 were found to be comparatively less active to 1 [3].
• AOalpha showed a relatively wide substrate specificity for 7 aldehydes tested, with high affinity to benzaldehyde and indole-3-aldehyde, while AOgamma could most efficiently oxidize naphthaldehyde [4].

References