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Chemical Compound Review:

Brolamfetamine 1-(4-bromo-2,5-dimethoxy- phenyl)propan-2...

Synonyms: Brolanfetamina, DOB-4, CHEMBL6607, SureCN714339, CHEBI:101090, ...

Szele, F.G. et al., Branchek, T. et al., Neal-Beliveau, B.S. et al., Ogren, S.O. et al., Titeler, M. et al., et al.

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Disease relevance of Brolamfetamine

The 5-HT1C/2 receptor agonist 2,5-dimethoxy-4-bromoamphetamine also completely reversed HAL-induced catalepsy, an effect blocked by ketanserin, but not pindolol [1].

High impact information on Brolamfetamine

The binding of the serotonin 5-hydroxytryptamine (5-HT)2 receptor agonists serotonin (5-HT) and 4-bromo-2,5-dimethoxyphenylisopropylamine is not affected by the presence of GTP analogs when the cloned 5-HT2 receptor is expressed in the 293 human embryonic kidney cell line [2].
3H-DOB (4-bromo-2,5-dimethoxyphenylisopropylamine) labels a guanyl nucleotide-sensitive state of cortical 5-HT2 receptors [3].
N-methyl derivatives of the 5-HT2 agonist 1-(4-bromo-2,5-dimethoxyphenyl)-2-aminopropane [4].

Biological context of Brolamfetamine

The hallucinogenic amphetamine derivative 4-bromo-2,5-dimethoxyphenylisopropylamine (DOB) has been shown to bind to a small number of binding sites with properties very similar to [3H]ketanserin-labeled 5-HT2 receptors, but with much higher agonist affinities [5].

Associations of Brolamfetamine with other chemical compounds

The 5-HT2 receptor was labelled with the agonist/hallucinogen radioligand 3H-DOB (4-bromo-2,5-dimethoxyphenylisopropylamine) [6].

Analytical, diagnostic and therapeutic context of Brolamfetamine

Intraventricular injections of galanin counteract development of head twitches induced by the 5-HT-2 agonist 1-(2,5-dimethoxyphenyl-4-bromo)-2-aminopropane [7].

References

Serotonergic involvement in haloperidol-induced catalepsy. Neal-Beliveau, B.S., Joyce, J.N., Lucki, I. J. Pharmacol. Exp. Ther. (1993) [Pubmed]
High affinity agonist binding to cloned 5-hydroxytryptamine2 receptors is not sensitive to GTP analogs. Szele, F.G., Pritchett, D.B. Mol. Pharmacol. (1993) [Pubmed]
3H-DOB (4-bromo-2,5-dimethoxyphenylisopropylamine) labels a guanyl nucleotide-sensitive state of cortical 5-HT2 receptors. Lyon, R.A., Davis, K.H., Titeler, M. Mol. Pharmacol. (1987) [Pubmed]
N-methyl derivatives of the 5-HT2 agonist 1-(4-bromo-2,5-dimethoxyphenyl)-2-aminopropane. Glennon, R.A., Titeler, M., Seggel, M.R., Lyon, R.A. J. Med. Chem. (1987) [Pubmed]
[3H]-DOB(4-bromo-2,5-dimethoxyphenylisopropylamine) and [3H] ketanserin label two affinity states of the cloned human 5-hydroxytryptamine2 receptor. Branchek, T., Adham, N., Macchi, M., Kao, H.T., Hartig, P.R. Mol. Pharmacol. (1990) [Pubmed]
Radioligand binding evidence implicates the brain 5-HT2 receptor as a site of action for LSD and phenylisopropylamine hallucinogens. Titeler, M., Lyon, R.A., Glennon, R.A. Psychopharmacology (Berl.) (1988) [Pubmed]
Intraventricular injections of galanin counteract development of head twitches induced by the 5-HT-2 agonist 1-(2,5-dimethoxyphenyl-4-bromo)-2-aminopropane. Ogren, S.O., Fuxe, K. Acta Physiol. Scand. (1989) [Pubmed]

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