Disease relevance of Nivral

• Quinidine enhanced thiodicarb toxicity in a dose-dependent manner, with mortality in the presence of P-gp inhibition increased up to 33% [1].

High impact information on Nivral

• Comparative Western and Northern blot studies indicate that expression of CYP9A1 in thiodicarb selected populations of tobacco budworm is associated with insecticide resistance [2].
• Field strains exhibited significantly greater percentage survival than the laboratory reference strain in the permethrin bioassays in 1996 and 1997 in both the P and F1 generation bioassays and in the thiodicarb bioassays in 1997 [3].
• Inhibition of P-gp decreased the LD50 for thiodicarb by a factor of 12 [4].
• The biochemistry and genetics of thiodicarb resistance were studied in the house fly, Musca domestica L [5].
• Bioassays of backcrosses and the F2 generation showed that the major gene(s) conferring resistance to thiodicarb were on chromosome II [5].

Chemical compound and disease context of Nivral

• Endosulfan and carbamates such as thiodicarb, methomyl and carbaryl had low intrinsic toxicities against both strains, with little difference in sensitivity between them [6].

Associations of Nivral with other chemical compounds

• The in vitro study revealed that the inhibition encountered by different concentration of both larvin and cypermethrin is of the irreversible non-competitive type [7].

Analytical, diagnostic and therapeutic context of Nivral

• Bioassays with several strains revealed that a thiodicarb-resistant strain was also resistant to carbaryl and to several organophosphates [5].

References