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Chemical Compound Review:

MNPN N-(2-cyanoethyl)-N-methyl- nitrous amide

Synonyms: CCRIS 398, AC1L1WLV, LS-124947, AKOS006278449, FT-0672055, ...

Prokopczyk, B. et al., Stich, H.F. et al., Prokopczyk, B. et al., Prokopczyk, B. et al.

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High impact information on MNPN

3-(Methylnitrosamino)propionitrile: occurrence in saliva of betel quid chewers, carcinogenicity, and DNA methylation in F344 rats [1].
Synthesis and kinetics of decomposition of 7-(2-cyanoethyl)guanine and O6-(2-cyanoethyl)guanine, markers for reaction of acrylonitrile and 3-(methylnitrosamino)propionitrile with DNA [2].
A study of betel quid carcinogenesis. IX. Comparative carcinogenicity of 3-(methylnitrosamino)propionitrile and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone upon local application to mouse skin and rat oral mucosa [3].
None of the other areca nut-related nitrosamines (N-nitrosoguvacine (NGC), 3-(methylnitrosamino)propionitrile (MNPN) and 3-(methylnitrosamino)propionaldehyde (MNPA)) were detected in the saliva of Taiwanese betel quid chewers [4].

Anatomical context of MNPN

The Areca-derived 3-(methylnitrosamino)propionitrile (MNPN) was tested for its tumor initiating activity on mouse skin and for its tumorigenic potential in the oral mucosa of rats [3].

References

3-(Methylnitrosamino)propionitrile: occurrence in saliva of betel quid chewers, carcinogenicity, and DNA methylation in F344 rats. Prokopczyk, B., Rivenson, A., Bertinato, P., Brunnemann, K.D., Hoffmann, D. Cancer Res. (1987) [Pubmed]
Synthesis and kinetics of decomposition of 7-(2-cyanoethyl)guanine and O6-(2-cyanoethyl)guanine, markers for reaction of acrylonitrile and 3-(methylnitrosamino)propionitrile with DNA. Prokopczyk, B., Bertinato, P., Hoffmann, D. Carcinogenesis (1988) [Pubmed]
A study of betel quid carcinogenesis. IX. Comparative carcinogenicity of 3-(methylnitrosamino)propionitrile and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone upon local application to mouse skin and rat oral mucosa. Prokopczyk, B., Rivenson, A., Hoffmann, D. Cancer Lett. (1991) [Pubmed]
Oral lesions, genotoxicity and nitrosamines in betel quid chewers with no obvious increase in oral cancer risk. Stich, H.F., Rosin, M.P., Brunnemann, K.D. Cancer Lett. (1986) [Pubmed]

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