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Chemical Compound Review:

Germall 11 1-[1,3-bis(hydroxymethyl)- 2,5-dioxo...

Synonyms: Germall II, SureCN34370, D5146_ALDRICH, D5146_SIGMA, SBB003028, ...

Perret, C.M. et al., Ramis, J. et al., de Groot, A.C. et al., Williams, R.O. et al., Kantor, G.R. et al.

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Disease relevance of Diazolidinylurea

Acute allergic contact dermatitis from diazolidinyl urea (Germall II) in a hair gel [1].
Contact sensitivity to diazolidinyl urea (Germall II) [2].
Diazolidinyl urea (DU; trade name Germall II), a new broad spectrum preservative, was tested from July 1984 to September 1988 in 2400 consecutive patients with eczemas possibly caused or complicated by a contact allergy [2].
2 other patients already sensitive to formaldehyde had exacerbations of dermatitis due to diazolidinyl urea [3].

High impact information on Diazolidinylurea

Based on the E25 formulation, two more dermal creams were prepared, E27 with benzyl alcohol and E28 with diazolidinyl urea as preservative agents [4].

Analytical, diagnostic and therapeutic context of Diazolidinylurea

Determination of diazolidinyl urea in a topical cream by high-performance liquid chromatography [5].

References

Acute allergic contact dermatitis from diazolidinyl urea (Germall II) in a hair gel. Kantor, G.R., Taylor, J.S., Ratz, J.L., Evey, P.L. J. Am. Acad. Dermatol. (1985) [Pubmed]
Contact sensitivity to diazolidinyl urea (Germall II). Perret, C.M., Happle, R. Arch. Dermatol. Res. (1989) [Pubmed]
Contact allergy to diazolidinyl urea (Germall II). de Groot, A.C., Bruynzeel, D.P., Jagtman, B.A., Weyland, J.W. Contact Derm. (1988) [Pubmed]
Influence of formulation on the in vitro transdermal penetration of flutrimazole. Ramis, J., Conte, L., Segado, X., Forn, J., Lauroba, J., Calpena, A., Escribano, E., Domenech, J. Arzneimittel-Forschung. (1997) [Pubmed]
Determination of diazolidinyl urea in a topical cream by high-performance liquid chromatography. Williams, R.O., Mahaguna, V., Sriwongjanya, M. J. Chromatogr. B Biomed. Sci. Appl. (1997) [Pubmed]

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