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Chemical Compound Review

Aminex     2-(4-chloro-2-methyl- phenoxy)ethanoic...

Synonyms: MCPA amine, AG-E-49487, SureCN4880562, LS-11319, CTK1A2549, ...
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Disease relevance of Methoxone

  • The fatty acids released by anaerobic bacteria in the culture media were ether-extracted and analysed with an Aminex HPX-87H column [1].
 

High impact information on Methoxone

  • Subsequent to either mild acid hydrolysis, alkali hydrolysis, or acetylation followed by acetolysis, the resulting products were fractionated by high-pressure liquid chromatography on an Aminex HPX-42A column [2].
  • Subsequent chromatography of the partially purified tRNA using high-speed, high-pressure liquid chromatography on RPC-5 and Aminex A-28 coupled with chromatography on BD-cellulose at acidic pH and on DEAE-Sephadex A-50 significantly shortened isolation time for milligram quantities of several pure tRNA species [3].
  • A glass column (150 x 6.6 mm i.d.) packed with Aminex A-5 cation-exchange resin (potassium form) following the slurry method was used as the analytical column, and an admixture of 10 mmol l-1 potassium sulfate and 10 mmol l-1 potassium hydroxide solution as the eluent (pH 12.2) [4].
  • In contrast, no increased retention due to Zn2+ was observed when tRNAPhe was chromatographed on Aminex A-28 [5].
  • The effect of zinc on the chromatographic behavior of four tRNAs was examined on RPC-5 and Aminex A-28 columns [5].
 

Biological context of Methoxone

  • Hydrolysates of DNA reacted with 14C-TRI in vitro and hydrolysates of RNA and DNA from selected organs were separated on Aminex A6 for quantitation of alkylation products [6].
  • 1. The site of hydrolysis of rabbit brain endo-oligopeptidase B acting on luteinizing hormone-releasing hormone (LH-RH) was determined by isolating the products by chromatography on Aminex A-5 resin developed with pyridine-acetic acid buffer [7].
  • The amount of PCA that reacted with the cellulosic material was determined by means of isocratic HPLC (Aminex HPX-87-H) [8].
 

Associations of Methoxone with other chemical compounds

  • 2-KLG is separated from other aldonic and ketoaldonic acids by high-performance liquid chromatography on an Aminex anion exchange column with ammonium formate or potassium phosphate as the eluant [9].
  • The identity of the products in vitro was confirmed by comparing their migration with that of light chains produced in vivo upon electrophoresis in sodium dodecylsulphate/polyacrylamide gels, and from the profiles of tryptic peptides obtained by chromatography on Aminex A-5 ion-exchange columns [10].
  • The analytical procedure consists of plasma protein precipitation with acetonitrile, acid extraction by chromatography through a DEAE-cellulose column eluted with 100 mM perchloric acid, HPLC by cation-exchange column Aminex HPX-87 eluted with 6.5 mM sulfuric acid [11].
  • 166Ho has been separated from the bulk dysprosium target with the help of HPLC using Aminex A7 ion exchanger resin and alpha-hydroxyisobutyric acid (alpha-HIBA) as the mobile phase [12].
  • The protein-free plasma metabolites of the tracer were analyzed using a cation-exchange column (Aminex A-6) eluted with a pH 4.25 citrate buffer [13].
 

Gene context of Methoxone

  • The column was an Aminex Ion Exclusion HPX 874 with a PRP precolumn, the mobile phase was 0.05% sulfuric acid-acetonitrile (88:12, v/v), the flow rate was 0.6 ml/min, the detection wavelength was 210 nm [14].
 

Analytical, diagnostic and therapeutic context of Methoxone

  • New HPLC conditions on Aminex A-6 were worked out which enable rapid separation of both ethenoadenosine and ethenocytidine from natural tRNA nucleosides [15].
  • Acid- and alkali-modified mannans were studied by proton magnetic resonance spectroscopy, and released products were analyzed by high-performance liquid chromatography on an Aminex HPX-42A column [16].
  • In the case of rat liver, compounds released by the liver are readily separated and quantitated, using a strong cation exchanger (Aminex HPX 87H), two detectors connected in series (ultraviolet detector at 210 nm and refractive index detector), and by optimizing the concentration of sulphuric acid in the mobile phase [17].

References

  1. A modified procedure for the identification of anaerobic bacteria by high performance liquid chromatography--quantitative analysis of short-chain fatty acids. Krausse, R., Ullmann, U. Zentralbl. Bakteriol. (1991) [Pubmed]
  2. Mannan composition of the hyphal form of two relatively avirulent mutants of Candida albicans. Saxena, A., McElhaney-Feser, G.E., Cihlar, R.L. Infect. Immun. (1990) [Pubmed]
  3. Purification of human placenta phenylalanine, valine, methionine, glucine, and serine transfer ribonucleic acids. Amandaraj, M.P., Roe, B.A. Biochemistry (1975) [Pubmed]
  4. Determination of 2,2,2-trichloroethanol in plasma and urine by ion-exclusion chromatography. Itoh, H., Ikeda, S., Ichinose, N. The Analyst. (1994) [Pubmed]
  5. Effect of zinc ions on tRNA structure. I. Reversed-phase chromatography. Flanagan, J.M., Jacobson, K.B. J. Chromatogr. (1987) [Pubmed]
  6. Interactions of trichloroethylene with DNA in vitro and with RNA and DNA of various mouse tissues in vivo. Bergman, K. Arch. Toxicol. (1983) [Pubmed]
  7. Brain endo-oligopeptidase B: inactivation of LH-RH by hydrolysis of the Pro9-Gly-NH2(10) peptide bond. Camargo, A.C., Spadaro, A.C., Martins, A.R., Greene, L.J. Braz. J. Med. Biol. Res. (1982) [Pubmed]
  8. Identification and quantification of cotton-bound, cyclic polycarboxylic acids by means of isocratic HPLC. Schramm, C., Rinderer, B. Analytical and bioanalytical chemistry. (2004) [Pubmed]
  9. Determination of 2-keto-L-gulonic and other ketoaldonic and aldonic acids produced by ketogenic bacterial fermentation. Lazarus, R.A., Seymour, J.L. Anal. Biochem. (1986) [Pubmed]
  10. Cell-free translation of messenger RNA for a myeloma light chain prepared from synchronised plasmacytoma cells. Abraham, K.A., Eikhom, T.S., Dowben, R.M., Garatun-Tejeldsto, O. Eur. J. Biochem. (1976) [Pubmed]
  11. 3-Hydroxy-3-methylglutaric, adipic, and 2-oxoglutaric acids measured by HPLC in the plasma from diabetic patients. Lippe, G., Trevisan, R., Nosadini, R., Fabris, R., Deana, R. Clin. Biochem. (1987) [Pubmed]
  12. Production of 166Ho through 164Dy(n, gamma)165Dy(n, gamma)166Dy(beta-)166Ho and separation of 166Ho. Lahiri, S., Volkers, K.J., Wierczinski, B. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. (2004) [Pubmed]
  13. Measurement of L-[methyl-11C]methionine in human plasma. Ishiwata, K., Kameyama, M., Hatazawa, J., Kubota, K., Ido, T. International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes. (1991) [Pubmed]
  14. A new HPLC method for pidotimod plasma levels determination. Dal Bo, L., Broccali, G.P., Silingardi, S., Coppi, G. Bollettino chimico farmaceutico. (1993) [Pubmed]
  15. The reaction of adenine and cytosine residues in tRNA with chloroacetaldehyde. Krzyzosiak, W.J., Biernat, J., Ciesiołka, J., Gulewicz, K., Wiewiórowski, M. Nucleic Acids Res. (1981) [Pubmed]
  16. Analysis of mannans of two relatively avirulent mutant strains of Candida albicans. Saxena, A., Hammer, C.F., Cihlar, R.L. Infect. Immun. (1989) [Pubmed]
  17. Simple cation-exchange high-performance liquid chromatography optimized to the measurement of metabolites in the effluents from perfused rat livers using refractive index and ultraviolet detectors. Masson, S., Sciaky, M., Desmoulin, F., Fontanarava, E., Cozzone, P.J. J. Chromatogr. (1991) [Pubmed]
 
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