Disease relevance of zinc dihydrate

• The EG intercalation was found to increase the dehydration temperature of the zinc hydroxide layers from 130 to 180 degrees C. So the thermally stable material is then promising as a new class of precursors in creating organic-inorganic nanocomposites [1].
• Pertussis toxin (0.25, 0.5, 1.0 micrograms/ml) and EGTA (1, 2, 5 mM) inhibited zinc hydroxide-induced O2- production in a dose-dependent manner [2].

Psychiatry related information on zinc dihydrate

• However, with increasing reaction time, the major Zn sorption mechanism shifted to the formation of a zinc hydroxide surface precipitate, with characteristic Zn-Zn bond distances of 3.07 A [3].

High impact information on zinc dihydrate

• From computer graphics analysis and MD simulations on the zinc hydroxide form of human carbonic anhydrase II we find that this interaction forces the hydroxide hydrogen atom to be in a "down" position relative to the deep water-binding pocket [4].
• We postulate that a zinc hydroxide complex, bound to the known A9/G10.1 metal ion binding site, abstracts the proton from the 2'-hydroxyl group of G8, which attacks the A9 phosphate and initiates cleavage [5].
• Our results are consistent with a zinc-hydroxide mechanism of action with for spinach CA, similar to that of animal carbonic anhydrases [6].
• These data indicate that the histidine ligands, although not essential for catalysis, are conserved to maximize electrostatic stabilization of both the ground-state zinc-hydroxide and the negatively charged transition state [7].
• We evaluated six deproteinizing methods for determination of uric acid in serum by "high-performance" liquid chromatography with ultraviolet detection: those involving zinc hydroxide, sodium tungstate, trichloroacetic acid, perchloric acid, acetonitrile, and centrifugal ultrafiltration (with Amicon MPS-1 devices) [8].

Biological context of zinc dihydrate

• Zinc hydroxide induced respiratory burst in rat neutrophils [2].
• Electronmicroscopy showed that neutrophils engulfed zinc hydroxide particles by phagocytosis [2].
• The inhibitors of protein kinase C, 1-(5-isoquinolinesulfonyl)-2-methyl-piperazine and N-[2-(methylamino)ethyl]-5-isoquinolinesulfonamide inhibited zinc hydroxide-induced O2- production with IC50 values ranging between 10 microM and 25 microM [2].
• These reactions, to our knowledge, are the first reported examples of thioester hydrolysis mediated by zinc hydroxide complexes [9].

Anatomical context of zinc dihydrate

• Zinc hydroxide stimulates superoxide production by rat alveolar macrophages [10].

Associations of zinc dihydrate with other chemical compounds

• Then again, for pH >/=6.5 and at higher sorption densities, Zn(II) ions may begin to form zinc-hydroxide-like polynuclear sorption complexes on the surfaces of the ferrihydrite, where R(Zn-Zn) approximately 3.53 A [11].
• X-ray diffraction (XRD) studies revealed that anionic vitamin C molecules are adsorbed between positively charged zinc hydroxide layers with a 1:1 layer sequence, since well-defined change in basal spacing was observed [12].
• Formazan deposits in alveolar macrophages, formed as a result of nitro blue tetrazolium reduction, were increased in zinc hydroxide-treated lung slices, suggesting that zinc hydroxide stimulated super oxide anion generation from alveolar macrophages [13].

Gene context of zinc dihydrate

• Thioester hydrolysis reactivity of zinc hydroxide complexes: investigating reactivity relevant to glyoxalase II enzymes [9].
• The zinc hydroxide injections were followed by an increase in proliferating cell nuclear antigen labeling indices in both alveolar macrophages and terminal bronchioles [13].

References