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Chemical Compound Review:

Prepodyne 2-methyloxirane; molecular iodine; oxirane

Synonyms: AC1L1XTS, LS-117931, 26617-87-8, POLOXAMER-IODONE, Poloxamer-iodine, ...

Parrott, P.L. et al., Davis, D. et al., Rausch, F.D. et al., Amortegui, A.J. et al., Anderson, R.L. et al.

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Disease relevance of POLOXAMER-IODONE

Pseudomonas aeruginosa peritonitis associated with contaminated poloxamer-iodine solution [1].
In view of recent reports of contamination of the fibreoptic bronchoscope by tuberculous and non-tuberculous mycobacteria, we evaluated the disinfecting properties of aqueous glutaraldehyde (Cidex) and an iodophor (Prepodyne) against Mycobacterium tuberculosis and M gordonae [2].
Investigations into the survival of Pseudomonas aeruginosa in poloxamer-iodine [3].

High impact information on POLOXAMER-IODONE

Culture surveys showed that a strain of Ps. aeruginosa of identical susceptibility pattern, plasmid profile, and serotype was present in bottles of a poloxamer-iodine solution unopened until the time of culture [1].
Two iodophor preparations, Betadine and Prepodyne, used as handwashing antiseptics in two well-baby nurseries, were compared [4].

Analytical, diagnostic and therapeutic context of POLOXAMER-IODONE

A successful treatment of yeast-infected ears was multiple otic lavages using a combination of an aqueous solution of poloxamer-iodine and application of an antifungal-antibiotic-corticosteroids ointment [5].

References

Pseudomonas aeruginosa peritonitis associated with contaminated poloxamer-iodine solution. Parrott, P.L., Terry, P.M., Whitworth, E.N., Frawley, L.W., Coble, R.S., Wachsmuth, I.K., McGowan, J.E. Lancet (1982) [Pubmed]
Disinfection of the flexible fibreoptic bronchoscope against Mycobacterium tuberculosis and M gordonae. Davis, D., Bonekat, H.W., Andrews, D., Shigeoka, J.W. Thorax (1984) [Pubmed]
Investigations into the survival of Pseudomonas aeruginosa in poloxamer-iodine. Anderson, R.L., Berkelman, R.L., Mackel, D.C., Davis, B.J., Holland, B.W., Martone, W.J. Appl. Environ. Microbiol. (1984) [Pubmed]
Comparison of the antiseptic effect of two Iodophor preparations on hand washing in a well-baby nursery. Amortegui, A.J., Buffenmyer, C. JOGN nursing; journal of obstetric, gynecologic, and neonatal nursing. (1978) [Pubmed]
Incidence and treatment of budding yeasts in canine otitis externa. Rausch, F.D., Skinner, G.W. Modern veterinary practice. (1978) [Pubmed]

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