Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

Tasmaderm (2E,4E,6E,8E)-N-ethyl-9-(4- methoxy-2,3,6...

Synonyms: Motretinid, Motretinida, Motretinide, Motretinidum, Tmmp-era, ...

Bollag, W., Zimmermann, B. et al., Christiansen, J. et al., Christiansen, J. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Tasmaderm

The compound: all-trans-N-ethyl-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenamide = Ro 11-1430, exerts a therapeutic influence on chemically induced papillomas and carcinomas of the skin of mice [1].
The retinoic acid derivative Ro 11-1430 (Tasmaderm) in patients with acne vulgaris not tolerating retinoic acid. A controlled multicenter trial against placebo [2].
The side-effects erythema, desquamation and burning were significantly less frequent with Ro 11-1430 than with retinoic acid [3].

High impact information on Tasmaderm

The influence of all-trans retinoic acid, 13-cis retinoid acid and two aromatic retinoids (Ro 10-1670, Ro 11-1430) on the chondrogenic differentiation of mesenchymal cells in vitro was studied electron-microscopically [4].

References

Therapy of epithelial tumors with an aromatic retinoic acid analog. Bollag, W. Chemotherapy. (1975) [Pubmed]
The retinoic acid derivative Ro 11-1430 (Tasmaderm) in patients with acne vulgaris not tolerating retinoic acid. A controlled multicenter trial against placebo. Christiansen, J., Gadborg, E., Hattel, T., Justesen, O., Ludvigsen, K., Møllenbach, K., Nørholm, A., Reymann, F., Schmidt, H. Dermatologica (1979) [Pubmed]
Treatment of acne vulgaris with the retinoic acid derivative Ro 11-1430. A controlled clinical trial against retinoic acid. Christiansen, J., Holm, P., Reymann, F. Dermatologica (1976) [Pubmed]
Retinoids inhibit the differentiation of embryonic-mouse mesenchymal cells in vitro. Zimmermann, B., Tsambaos, D. Arch. Dermatol. Res. (1985) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

Editor

Share