Disease relevance of tetraphenylarsenic

• Surprisingly, discrete mutations in the predicted nucleotide binding folds of mdr1 that abolish drug resistance in mammalian cells have no apparent effect on TPA+ efflux via mdr1 in E. coli [1].

High impact information on tetraphenylarsenic

• SR CaATPase inhibition apparently is not a general property of lipophilic cations since the hydrophobic anion tetraphenylboron inhibited catalysis, whereas its cationic analog, tetraphenylarsonium, did not [2].
• The lipophilic anion tetraphenylboron (TPB-) but not the lipophilic cation tetraphenylarsonium (TPA+) inhibited ATP-dependent Ca2+ accumulation by isolated sarcoplasmic reticulum [3].
• Tetraphenylarsonium (TPA+) inhibited energy transduction in oxidative phosphorylation in mitochondria but not in submitochondrial particles, which are inside-out relative to the membranes of mitochondria [4].
• Anisotropic inhibition of energy transduction in oxidative phosphorylation in rat liver mitochondria by tetraphenylarsonium [4].
• Tetraphenylborate (Delta G(hydr) = -168 kJ mol(-1)) was found to have a significantly stronger interaction with water than either tetraphenylarsonium (Delta G(hydr) = -145 kJ mol(-1)) or tetraphenylphosphonium (Delta G(hydr) = -157 kJ mol(-1)) [5].

Biological context of tetraphenylarsenic

• A dry powder formulation of terbutaline sulphate was radiolabeled for inhalation by Turbuhaler (AstraZeneca) using the water-soluble salt sodium pertechnetate and the water-insoluble salt tetraphenylarsonium pertechnetate [6].

Anatomical context of tetraphenylarsenic

• The permeability and partition coefficients of tetraphenylarsonium (TPA) and several other organic cations were studied in the human erythrocyte using an ion-selective electrode [7].
• The quenching caused by lysosomes was reversed by lipophilic cations, tetraphenylarsonium (TPA) or triphenylmethylphosphonium (TPMP) [8].
• Small lipid-soluble cations, such as tetraphenylphosphonium (TPP+) and tetraphenylarsonium (TPA+) are frequently used as probes of membrane voltage (delta psi, or Vm) for small animal cells, organelles, and vesicles [9].

Associations of tetraphenylarsenic with other chemical compounds

• Solution-phase continuous and laser flash photolysis of the tetraphenylarsonium salt of the fac-[CH(3)Ir(CO)(2)I(3)](-) anion (1a) under excess carbon monoxide resulted in migratory insertion to give the acyl complex ion mer,trans-[Ir(C(O)CH(3))(CO)(2)I(3)](-) (2a) [10].

Gene context of tetraphenylarsenic

• Aliphatic alcohols are found to stimulate the transmembrane fluxes of a hydrophobic cation (tetraphenylarsonium, TPA) and anion (AN-12) 5-20 times in red blood cells [11].

References