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Chemical Compound Review:

Antimony-124 antimony

Synonyms: AC1O3RNX, 124Sb, 14683-10-4, Antimony, isotope of mass 124

Quarez, E. et al., Rabbitt, P. et al., Kim, H.A. et al., Matsumura, Y. et al., Singh, R. et al., et al.

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Disease relevance of antimony

INTERVENTION: Antimony, 20 mg/kg body weight intravenously every day for 28 days [1].
Visceral Leishmaniasis, or Kala Azar (KA): High Incidence of Refractoriness to Antimony Is Contributed by Anthroponotic Transmission via Post-KA Dermal Leishmaniasis [2].
1 Antimony (Sb), an industrial and environmental toxicant, is known to cause dermatitis and pulmonary inflammations, but the immunomodulatory effects of environmental or occupational exposure to Sb have not been reported [3].
METHODS: A combination of radio-labelled Antimony Sulphide and Patent Blue dye injected around the anal cancer enable identification of the sentinel node in the groin, using a gamma probe and direct visualization of the blue node [4].

High impact information on antimony

The nature of the thermoelectric materials Ag(1-x)Pb(m)SbTe(m+2) or LAST-m materials (LAST for Lead Antimony Silver Tellurium) with different m values at the atomic as well as nanoscale was studied with powder/single-crystal X-ray diffraction, electron diffraction, and high-resolution transmission electron microscopy [5].

Analytical, diagnostic and therapeutic context of antimony

1) Antimony (Sb) microelectrodes with tips of 2 to 5 micrometers in outside diameter were constructed, and their electromotive forces (EMF) were tested in response to the pH of several calibration buffers [6].

References

Efficacy and toxicity of sodium stibogluconate for mucosal leishmaniasis. Franke, E.D., Wignall, F.S., Cruz, M.E., Rosales, E., Tovar, A.A., Lucas, C.M., Llanos-Cuentas, A., Berman, J.D. Ann. Intern. Med. (1990) [Pubmed]
Visceral Leishmaniasis, or Kala Azar (KA): High Incidence of Refractoriness to Antimony Is Contributed by Anthroponotic Transmission via Post-KA Dermal Leishmaniasis. Singh, R., Kumar, D., Ramesh, V., Negi, N.S., Singh, S., Salotra, P. J. Infect. Dis. (2006) [Pubmed]
Altered serum cytokine and immunoglobulin levels in the workers exposed to antimony. Kim, H.A., Heo, Y., Oh, S.Y., Lee, K.J., Lawrence, D.A. Human & experimental toxicology. (1999) [Pubmed]
Sentinel lymph node biopsy for squamous cell carcinoma of the anal canal. Rabbitt, P., Pathma-Nathan, N., Collinson, T., Hewett, P., Rieger, N. ANZ journal of surgery. (2002) [Pubmed]
Nanostructuring, compositional fluctuations, and atomic ordering in the thermoelectric materials AgPb(m)SbTe(2+m). The myth of solid solutions. Quarez, E., Hsu, K.F., Pcionek, R., Frangis, N., Polychroniadis, E.K., Kanatzidis, M.G. J. Am. Chem. Soc. (2005) [Pubmed]
Physicochemical characteristics of antimony microelectrode with special reference to selection of standard buffers. Matsumura, Y., Satake, N., Fujimoto, M. Jpn. J. Physiol. (1980) [Pubmed]

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