High impact information on difluoromethane

• This effect is consistent with the view that difluoromethylene fatty acyl chains function in a manner approximating that of unsaturated fatty acyl chains [1].
• Pressure effects on Friedel-Crafts alkylation reactions in supercritical difluoromethane [2].
• Difluoroenoxysilanes, prepared from acylsilanes and trifluoromethyltrimethylsilane under fluoride activation, were glycosylated with some glycosyl donors (acylglycosides, glycals) to yield difluoro-C-glycosides with a difluoromethylene group in the place of the anomeric oxygen [3].
• However, the germinal difluoromethylene fatty acids commonly employed as 19F membrane probes appear to appreciably perturb the organization of model membranes and biomembranes [4].
• A new fluorinated bisphosphonate, difluoromethylene bisphosphonate (F2MBP), was studied for its effects on physiologic bone remodeling in the actively growing rat tibia [5].

Biological context of difluoromethane

• A series of short-chain analogues of N-palmitoylsphingosine-1-phosphate, modified by replacement of the phosphate and the long alkenyl side chain with hydrolytically stable difluoromethylene phosphonate and phenyl, respectively, were prepared to study the structure-activity relationship for inhibition of sphingomyelinase [6].
• The inhalation toxicology, genetic toxicology, and metabolism of difluoromethane in the rat [7].

Associations of difluoromethane with other chemical compounds

• The difluoromethylene group as a replacement for the labile oxygen in steroid sulfates: a new approach to steroid sulfatase inhibitors [8].

Gene context of difluoromethane

• Difluoroallenyl bromide as a wide-ranging difluoromethylene cation equivalent: SN2 substitution of difluoropropargyl bromide through sequential SE2' and SN2' reactions [9].

Analytical, diagnostic and therapeutic context of difluoromethane

• 1. Difluoromethane (HFC32) is under development as a replacement for chlorofluorocarbons (CFCs) in some refrigeration applications [10].

References