Chemical Compound Review:
CGP-39551 [(E)-4-amino-4- ethoxycarbonyl-2-methyl- but...
Synonyms:
Cgp 39551, LS-183922, AC1O4M9I, 127910-32-1, MolPort-003-983-537
- Anticonvulsant activity of two orally active competitive N-methyl-D-aspartate antagonists, CGP 37849 and CGP 39551, against sound-induced seizures in DBA/2 mice and photically induced myoclonus in Papio papio. Chapman, A.G., Graham, J.L., Patel, S., Meldrum, B.S. Epilepsia (1991)
- The orally active NMDA receptor antagonist CGP 39551 ameliorates the high pressure neurological syndrome in Papio anubis. Pearce, P.C., Halsey, M.J., Maclean, C.J., Ward, E.M., Pearson, J., Henley, M., Meldrum, B.S. Brain Res. (1993)
- The effects of NMDA receptor antagonists at anticonvulsive doses on the performance of rats in the water maze task. Ylinen, A., Pitkänen, M., Sirviö, J., Hartikainen, T., Sivenius, J., Koivisto, E., Riekkinen, P.J. Eur. J. Pharmacol. (1995)
- Central effects of CGP 37849 and CGP 39551, competitive NMDA receptor antagonists, in mice. Maj, J., Rogóz, Z., Skuza, G. Polish journal of pharmacology. (1993)
- Long-lasting effects of chronic neonatal blockade of N-methyl-D-aspartate receptor through the competitive antagonist CGP 39551 in rats. Facchinetti, F., Dall'Olio, R., Ciani, E., Sparapani, M., Virgili, M., Contestabile, A. Neuroscience (1994)
- Chronic neonatal blockade of N-methyl-D-aspartate receptor by CGP 39551 increases dopaminergic function in adult rat. Dall'Olio, R., Facchinetti, F., Contestabile, A., Gandolfi, O. Neuroscience (1994)
- Ionotropic and metabotropic glutamate receptor antagonism attenuates cue-induced cocaine seeking. Bäckström, P., Hyytiä, P. Neuropsychopharmacology (2006)
- Blockade of the NMDA receptor increases developmental apoptotic elimination of granule neurons and activates caspases in the rat cerebellum. Monti, B., Contestabile, A. Eur. J. Neurosci. (2000)
- Sensitisation to repeated withdrawal, in mice treated chronically with diazepam, is blocked by an NMDA receptor antagonist. Dunworth, S.J., Stephens, D.N. Psychopharmacology (Berl.) (1998)
- Anxiolytic activity of glycine-B antagonists and partial agonists--no relation to intrinsic activity in the patch clamp. Karcz-Kubicha, M., Jessa, M., Nazar, M., Plaznik, A., Hartmann, S., Parsons, C.G., Danysz, W. Neuropharmacology (1997)
- NMDA receptor antagonists inhibit ethanol-produced locomotor stimulation in NMRI mice. Liljequist, S. Alcohol (1991)
- Excitatory amino acid antagonists and pentylenetetrazol-induced seizures during ontogenesis. IV. Effects of CGP 39551. Velísek, L., Vachová, D., Mares, P. Pharmacol. Biochem. Behav. (1997)
- Some central effects of CGP 37849 and CGP 39551, the competitive NMDA receptor antagonists: potential antiparkinsonian activity. Maj, J., Skuza, G., Rogóz, Z. Journal of neural transmission. Parkinson's disease and dementia section. (1993)
- CGP 37849 and CGP 39551: novel and potent competitive N-methyl-D-aspartate receptor antagonists with oral activity. Fagg, G.E., Olpe, H.R., Pozza, M.F., Baud, J., Steinmann, M., Schmutz, M., Portet, C., Baumann, P., Thedinga, K., Bittiger, H. Br. J. Pharmacol. (1990)
- Effects of the novel NMDA receptor antagonist, CGP 39551, on field potentials and the induction and expression of LTP in the dentate gyrus in vivo. Maren, S., Baudry, M., Thompson, R.F. Synapse (1992)
- Effects of competitive NMDA receptor antagonists on excitatory amino acid-evoked currents in mouse spinal cord neurones. D'Hooge, R., Raes, A., Van de Vijver, G., Van Bogaert, P.P., De Deyn, P.P. Fundamental & clinical pharmacology. (1999)
- Preservation of hippocampal NMDA receptors may be crucial for spatial learning after epileptic seizures in rats. Lahtinen, H., Ylinen, A., Hyvönen, M., Sirviö, J., Miettinen, R., Riekkinen, P.J. Brain Res. (1993)
- Adaptive changes in the NMDA receptor complex in rat hippocampus after chronic treatment with CGP 39551. Mennini, T., Miari, A., Presti, M.L., Rizzi, M., Samanin, R., Vezzani, A. Eur. J. Pharmacol. (1994)
- Weak anticonvulsant activity of CGP 37849 and CGP 39551 against kindled seizures following systemic administration. Cotterell, K.L., Croucher, M.J., Bradford, H.F. Eur. J. Pharmacol. (1992)
- Effects of post-ethanol administration of NMDA and non-NMDA receptor antagonists on the development of ethanol tolerance in C57B1 mice. Karcz-Kubicha, M., Liljequist, S. Psychopharmacology (Berl.) (1995)
- Protection from kainic acid neuropathological syndrome by NMDA receptor antagonists: effect of MK-801 and CGP 39551 on neurotransmitter and glial markers. Virgili, M., Migani, P., Contestabile, A., Barnabei, O. Neuropharmacology (1992)
- Comparison of competitive and uncompetitive NMDA receptor antagonists with regard to monoaminergic neuronal activity and behavioural effects in rats. Löscher, W., Annies, R., Hönack, D. Eur. J. Pharmacol. (1993)
- Differential behavioural and neurochemical effects of competitive and non-competitive NMDA receptor antagonists in rats. Bubser, M., Keseberg, U., Notz, P.K., Schmidt, W.J. Eur. J. Pharmacol. (1992)
- Comparative analysis of different competitive antagonists interaction with NR2A and NR2B subunits of N-methyl-D-aspartate (NMDA) ionotropic glutamate receptor. Blaise, M.C., Sowdhamini, R., Pradhan, N. Journal of molecular modeling (Online) (2005)
- Anticonvulsant and behavioral effects of two novel competitive N-methyl-D-aspartic acid receptor antagonists, CGP 37849 and CGP 39551, in the kindling model of epilepsy. Comparison with MK-801 and carbamazepine. Löscher, W., Hönack, D. J. Pharmacol. Exp. Ther. (1991)
- Neuronal nitric oxide synthase is permanently decreased in the cerebellum of rats subjected to chronic neonatal blockade of N-methyl-D-aspartate receptors. Virgili, M., Facchinetti, F., Sparapani, M., Tregnago, M., Lucchi, R., Dall'Olio, R., Gandolfi, O., Contestabile, A. Neurosci. Lett. (1998)