Disease relevance of chlorpheniramine

• Urethral pressure profiles before and after Ornade administration in patients with stress urinary incontinence [1].
• The efficacy of piriton on chloroquine-induced pruritus in patients with malaria [2].
• Death attributed to ventricular arrhythmia induced by thioridazine in combination with a single Contac C capsule [3].
• The effect on labour of 50 mg intravaginal PG F2 alpha or a standard intravenous oxytocin regimen was compared in 2 randomised trials involving a total of 83 patients, 23 of whom had experienced spontaneous rupture of the membranes (S.R.O.M.) and 60 of whom had artificial rupture of the membranes (A.R.M.) to induce labour [4].

Psychiatry related information on chlorpheniramine

• Phenylpropanolamine (Ornade), 25-50 mg at bedtime, stabilizes the vesicosphincteric unit and stopped bedwetting in 11 of 16 patients [5].

High impact information on chlorpheniramine

• Here we report for the first time that a protein, identified by a monoclonal antibody to be the Mt heat shock protein (Baird, P.N., L.M. Hall, and A.R.M. Coates. 1989. J. Gen. Microbiol. 135:931-939) chaperonin (cpn) 10, is responsible for the osteolytic activity of this bacterium [6].
• Supine diastolic blood-pressure rose to 100 mm Hg or more in 12 out of 37 subjects taking an anorectic preparation ('Trimolets'; 85 mg phenylpropanolamine per capsule) and in 4 out of 34 subjects taking a decongestant preparation ('Contac 500'; 50 mg phenylpropanolamine per capsule) [7].
• It is believed that the phenylpropanolamine component of Ornade stimulates alpha-adrenergic receptors at the vesical neck and in the proximal urethra to achieve the therapeutic effect of reducing or eliminating stress urinary incontinence [1].
• It is well known that in the fully developed allergic contac reaction a marked cellular infiltrate takes place in the upper corium and epidermis [8].

References