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Chemical Compound Review:

AC1O5FRF (4R)-2,2,6a,6b,9,9,12a- heptamethyl-4-[(Z)...

Synonyms: LS-98304

Seawright, A.A. et al., Sharma, S. et al., Sharma, S. et al., Sharma, O.P. et al., Pass, M.A., et al.

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Disease relevance of LANTADENE A

Lantadene A content and toxicity of the lantana plant (Lantana camara, Linn.) to guinea pigs [1].
Detoxification of lantana hepatotoxin, lantadene A, using Alcaligenes faecalis [2].
Lantadene A (LA) administered orally to guinea pigs elicited cholestasis [3].

High impact information on LANTADENE A

Liver homogenates, bile, gall bladder, blood, urine, contents of gastrointestinal tract (GIT) and faeces were analysed for the principal hepatotoxin in lantana leaves viz. lantadene A (LA), its congeners and biotransformation products, using high performance liquid chromatographic technique [4].
Disposition of lantadene A, the pentacyclic triterpenoid hepatotoxin, orally administered to guinea pigs [3].
Biotransformation of lantadene A (22 beta-angeloyloxy-3-oxoolean-12-en-28-oic acid), the pentacyclic triterpenoid, by Alcaligenes faecalis [5].
The interrelation of molecular structure and biological activity of lantadene A and C has been discussed [6].
Lantana poisoning in ruminants results from the ingestion of toxic varieties of the plant Lantana camara, which contain the triterpene acids lantadene A and lantadene B [7].

Chemical compound and disease context of LANTADENE A

Reduced lantadene A because of its low concentration in the leaves (5% of lantadene A) and lantadene B because of its significantly lower toxicity are thus unlikely to be of much importance in the poisoning of ruminants following consumption of the plant [8].

Biological context of LANTADENE A

Lantadene A, the toxic principle of lantana plant caused just marginal inhibition of lipid peroxidation in guinea pig liver homogenates [9].

Associations of LANTADENE A with other chemical compounds

Toxic Lantana camara taxa growing in Queensland all contain the triterpene acids lantadene A, reduced lantadene A and lantadene B [8].

Analytical, diagnostic and therapeutic context of LANTADENE A

A partially purified toxin fraction and lantadene A were obtained from Lantana camara L. leaves by batch extraction, column chromatography and fractional crystallization [10].
Form I of lantadene A was non-toxic to guinea pigs on oral administration [11].

References

Lantadene A content and toxicity of the lantana plant (Lantana camara, Linn.) to guinea pigs. Sharma, O.P., Makkar, H.P., Pal, R.N., Negi, S.S. Toxicon (1980) [Pubmed]
Detoxification of lantana hepatotoxin, lantadene A, using Alcaligenes faecalis. Singh, A., Sharma, O.P., Kurade, N.P., Ojha, S. Journal of applied toxicology : JAT. (2001) [Pubmed]
Disposition of lantadene A, the pentacyclic triterpenoid hepatotoxin, orally administered to guinea pigs. Sharma, S., Sharma, O.P., Dawra, R.K., Bhat, T.K. Toxicol. Lett. (1999) [Pubmed]
Biotransformation of lantadenes, the pentacyclic triterpenoid hepatotoxins of lantana plant, in guinea pig. Sharma, S., Sharma, O.P., Singh, B., Bhat, T.K. Toxicon (2000) [Pubmed]
Biotransformation of lantadene A (22 beta-angeloyloxy-3-oxoolean-12-en-28-oic acid), the pentacyclic triterpenoid, by Alcaligenes faecalis. Singh, A., Sharma, O.P., Dawra, R.K., Kanwar, S.S., Mahato, S.B. Biodegradation (1999) [Pubmed]
Biological action of lantadene C, a new hepatotoxicant from Lantana camara var. aculeata. Sharma, O.P., Vaid, J., Pattabhi, V., Bhutani, K.K. J. Biochem. Toxicol. (1992) [Pubmed]
Current ideas on the pathophysiology and treatment of lantana poisoning of ruminants. Pass, M.A. Aust. Vet. J. (1986) [Pubmed]
The oral toxicity for sheep of triterpene acids isolated from Lantana camara. Seawright, A.A., Hrdlicka, J. Aust. Vet. J. (1977) [Pubmed]
Effect of Lantana camara toxicity on lipid peroxidation in guinea pig tissues. Sharma, D.P., Dawra, R.K., Makkar, H.P. Res. Commun. Chem. Pathol. Pharmacol. (1982) [Pubmed]
Isolation and partial purification of Lantana (Lantana camara L.) toxins. Sharma, O.P., Dawra, R.K., Makkar, H.P. Toxicol. Lett. (1987) [Pubmed]
Molecular structure, polymorphism, and toxicity of lantadene A, the pentacyclic triterpenoid from the hepatotoxic plant Lantana camara. Sharma, O.P., Dawra, R.K., Pattabhi, V. J. Biochem. Toxicol. (1991) [Pubmed]

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