Disease relevance of Stamycin

• The morphological effects of an aqueous solution of Nistatin, of Clostridium septicum and Tityus serrulatus toxins, of Bothrops jararaca and Agkistrodon piscivorus venoms on the vessels of the tendinous portion of the diaphragm were investigated in guinea-pigs [1].
• The reproductive and developmental toxicity of the antifungal drug Nyotran (liposomal nystatin) in rats and rabbits [2].
• Inhibition of HIV-1 replication in H9 cells by nystatin-A compared with other antiviral agents [3].
• In the SEG III study, lactational body weights of the F1 generation were decreased at all Nyotran dose levels [2].
• Clinical relapses were observed in 15 patients (Candio-Hermal: n = 9; Lederlind: n = 6) [4].

High impact information on Stamycin

• Because of these findings and because Nistatin when injected intrapleurally induces an intense perineuritis of the phrenic nerve, a tentative hypothesis is proposed linking haemorrhagic exudation to the antidromic stimulation of sensitive nerves [1].
• Electrical or chemical stimulation of the phrenic nerve had effects on the microcirculation of the diaphragm similar to those of Nistatin, toxins and venoms [1].
• The comparative drug dispositions, urinary pharmacokinetics, and effects on renal function of multilamellar liposomal nystatin (LNYS; Nyotran) and amphotericin B deoxycholate (DAMB; Fungizone) were studied in rabbits [5].
• In SEG II studies, rats and rabbits were also administered 0.5, 1.5, or 3.0 mg/kg/day of Nyotran during gestation [2].
• Despite the parentally toxic doses in the SEG I study, there was no effect of Nyotran on F0 male or female fertility or early embryonic development of F1 offspring [2].

Associations of Stamycin with other chemical compounds

• Exsheathed larvae were cultivated in vitro in RPMI-1640 (Gibco-BRL, pH 7.2) containing 20% newborn Calf serum, 200 U Moronal/ml, and 200 U penicillin/streptomycin/ml [6].
• In a prospective open randomized multicentre study involving 12 paediatricians in private practice, Candio-Hermal and Lederlind were compared with miconazole oral gel (Daktar, Janssen) in 95 infants with oral thrush (candidosis) [4].
• Nystatin LF (Nyotran) is a liposomal, intravenous nystatin formulation under development by Aronex, under license from the MD Anderson Cancer Research Center, as a systemic antifungal agent against strains including Aspergillus and Candida [7].

Gene context of Stamycin

• Nystatin-A treatment inhibited RT activity by 85% and p24 production by 90% [3].
• In December 1997, Aronex, together with Grupo Ferrer Internacional, filed an MAA in Spain seeking approval for Nyotran for the treatment of systemic fungal infections [7].

References