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Chemical Compound Review

Ralitolina     (2Z)-N-(2-chloro-6-methyl- phenyl)-2-(3...

Synonyms: Ralitoline, Ralitolinum, GOE-4942, CI-946, LS-151109, ...
 
 
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Disease relevance of CI-946

 

Psychiatry related information on CI-946

  • In the maximal electroshock seizure test (mice), this compound showed marked anticonvulsant effects (ED50 2.8 mg/kg i.p.). The efficacy of clinically established anti-epileptics was significantly increased when ralitoline was given as co-medication [1].
 

High impact information on CI-946

 

Chemical compound and disease context of CI-946

 

Analytical, diagnostic and therapeutic context of CI-946

  • In unrestrained rats with chronically implanted electrodes, ralitoline (5 mg/kg) significantly reduced the duration of electrically-evoked hippocampal discharges and raised the focal stimulation threshold (10 mg/kg) [1].

References

 
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