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Chemical Compound Review:

Miporamicin (1R,2R,3R,6E,8S,9S,10S,12R,14E ,16R)-9-[(2S...

Synonyms: Mirosamicin, Mirosamicina, Mirosamicine, Mirosamicinum, Mycinamicin II, ...

Anzai, Y. et al., Horie, M. et al., Inouye, M. et al., Anzai, Y. et al., Nakajima, C. et al.

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Disease relevance of Mycinamicin II

A DNA fragment of 42 kb encompassing one of the mycinamicin II (Mm)-resistance-encoding genes, myrB, from a Mm-producing strain, Micromonospora griseorubida, was cloned in Escherichia coli using the cosmid vector pJB8 [1].
Disposition of mirosamicin in honeybee hives [2].

High impact information on Mycinamicin II

When the bioconversion to mycinamicin II (M-II) from PML-IV was performed using M7A21 and the feeding culture method, the productivity of M-II was the same as that of M-II in wild-type strain A11725. p446M7 containing mycAV was constructed using the Escherichia coli-Streptomyces shuttle vector pGM446 [3].
All of the products from the 22 ORFs are responsible for the biosynthesis of mycinamicin II and self-protection against the compounds synthesized [4].

Analytical, diagnostic and therapeutic context of Mycinamicin II

Determination of mirosamicin in animal tissues by high-performance liquid chromatography [5].
A simple and rapid method using high-performance liquid chromatography (HPLC) for the determination of mirosamicin in animal tissues has been developed [5].

References

A gene encoding mycinamicin III O-methyltransferase from Micromonospora griseorubida. Inouye, M., Suzuki, H., Takada, Y., Muto, N., Horinouchi, S., Beppu, T. Gene (1994) [Pubmed]
Disposition of mirosamicin in honeybee hives. Nakajima, C., Sakogawa, T., Okayama, A., Nakamura, A., Hayama, T. J. Vet. Pharmacol. Ther. (1998) [Pubmed]
The targeted inactivation of polyketide synthase mycAV in the mycinamicin producer, Micromonospora griseorubida, and a complementation study. Anzai, Y., Ishii, Y., Yoda, Y., Kinoshita, K., Kato, F. FEMS Microbiol. Lett. (2004) [Pubmed]
Organization of the biosynthetic gene cluster for the polyketide macrolide mycinamicin in Micromonospora griseorubida. Anzai, Y., Saito, N., Tanaka, M., Kinoshita, K., Koyama, Y., Kato, F. FEMS Microbiol. Lett. (2003) [Pubmed]
Determination of mirosamicin in animal tissues by high-performance liquid chromatography. Horie, M., Saito, K., Nose, N., Oka, H., Nakazawa, H. J. Chromatogr. B, Biomed. Appl. (1994) [Pubmed]

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