Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AC1O5P4V (4R,4aS,6aR,6aS,6bR,10S,12aS,1 4bS)-10...

Synonyms: 13224-63-0, Reduced lantadene A, Lantadene A (reduced), 22beta-Angeloyloxyoleanolic acid

Pass, M.A. et al., Sharma, S. et al., Pass, M.A. et al.

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Disease relevance of Reduced lantadene A

Studies on the mechanism of toxicity of reduced lantadene A in rats [1].
Observation of metabolites of reduced lantadene A in bile canalicular membranes of rats with triterpene-induced cholestasis [2].

High impact information on Reduced lantadene A

LA and its biotransformation product reduced lantadene A (RLA) could be detected in caecum, large intestine, and faeces [3].

References

Studies on the mechanism of toxicity of reduced lantadene A in rats. Pass, M.A., Pugh, M.W., Findlay, L. Biochem. Pharmacol. (1981) [Pubmed]
Observation of metabolites of reduced lantadene A in bile canalicular membranes of rats with triterpene-induced cholestasis. Pass, M.A., Goosem, M.W. Chem. Biol. Interact. (1982) [Pubmed]
Disposition of lantadene A, the pentacyclic triterpenoid hepatotoxin, orally administered to guinea pigs. Sharma, S., Sharma, O.P., Dawra, R.K., Bhat, T.K. Toxicol. Lett. (1999) [Pubmed]

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