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Chemical Compound Review

AC1O5QO2     N,N'-bis[(3,4- dimethoxyphenyl)methyl]-N...

Synonyms: 103190-36-9, Sdb-ethylenediamine
 
 
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High impact information on Sdb-ethylenediamine

  • Since the structure of SDB-ethylenediamine resembles that of verapamil, a calcium-blocking agent that overcomes drug resistance, it was checked for calcium-blocking activity [1].
  • We conclude that these analogues of SDB-ethylenediamine may have dual therapeutic advantage because (i) they are preferentially toxic for MDR cells when administered alone and (ii) they potentiate the cytotoxicity of Pgp-transported anticancer drugs [2].
  • Two out of seven new analogues of the known N,N'-bis(3,4-dimethoxybenzyl)-N-solanesylethylenediamine (SDB-ethylenediamine), namely, compounds with C10 and C15 side chains, at low micromolar concentrations were preferentially toxic for several mammalian tumor cell lines that acquired MDR during prolonged drug selection [2].
  • Unlike verapamil and cepharanthine, SDB-ethylenediamine did not greatly inhibit the efflux of [3H]DNR from V79/ADM, the binding of [3H]vinblastine to membrane vesicles of V79/ADM, or the binding of [3H]azidopine to P-glycoprotein in the cytoplasmic membrane of V79/ADM [3].

References

  1. Overcoming drug resistance in cancer cells with synthetic isoprenoids. Yamaguchi, T., Nakagawa, M., Shiraishi, N., Yoshida, T., Kiyosue, T., Arita, M., Akiyama, S., Kuwano, M. J. Natl. Cancer Inst. (1986) [Pubmed]
  2. Effects of isoprenoid analogues of SDB-ethylenediamine on multidrug resistant tumor cells alone and in combination with chemotherapeutic drugs. Sidorova, T.A., Nigmatov, A.G., Kakpakova, E.S., Stavrovskaya, A.A., Gerassimova, G.K., Shtil, A.A., Serebryakov, E.P. J. Med. Chem. (2002) [Pubmed]
  3. Novel mechanism of N-solanesyl-N,N'-bis(3,4-dimethoxybenzyl)ethylenediamine in potentiation of antitumor drug action on multidrug-resistant and sensitive Chinese hamster cells. Tomida, A., Tatsuta, T., Suzuki, H. Jpn. J. Cancer Res. (1991) [Pubmed]
 
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