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Chemical Compound Review

YM-264     but-2-enedioic acid; [4-(3-methyl-3-phenyl...

Synonyms: SureCN9819910, AC1O5RFQ, YM 264
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High impact information on [4-(3-methyl-3-phenyl-butyl)piperazin-1-yl]-(2-pyridin-3-ylthiazolidin-4-yl)methanone

  • In addition, the PAF antagonists WEB 2086 and YM 264 strongly inhibited the migration of neutrophils across IL-1-treated endothelial monolayers [1].
  • The role of platelet-activating factor (PAF) in stimulating neutrophils during interaction with HUVEC has been investigated using the specific PAF receptor antagonists WEB 2086 and YM 264 [1].
  • Structurally-unrelated PAF antagonists (SM-12502, TCV-309 and YM-264), none of which showed any appreciable inhibitory activity against PAF acetylhydrolase, did not block granule cell migration under the same conditions [2].

References

 
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