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Chemical Compound Review:

RH-237 4-[4-[(1E,3E,5E)-6-[4- (dibutylamino)phenyl...

Synonyms: AR-1F6184, RH 237, AC1O5S5J, AC1Q22PC, 892-52-4, ...

This record was replaced with 6439668.

Gillis, A.M. et al., Omichi, C. et al., Fast, V.G. et al., Fast, V.G. et al., Fast, V.G. et al., et al.

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High impact information on 4-[4-[(1E,3E,5E)-6-[4-(dibutylamino)phenyl]hexa-1,3,5-trienyl]-1-pyridyl]butane-1-sulfonic acid

Changes in transmembrane potential relative to action potential amplitude (delta Vm/APA) were measured in patterned cultures of neonatal rat myocytes, stained with voltage-sensitive dye (RH-237), by optical mapping (96-channel photodiode array, 6- to 30-micron resolution) during the application of EES (field strength, 8 to 22 V/cm; duration, 6 ms) [1].
Action potential upstrokes were measured by using 12 photodiodes selected within a 10x10 diode array and a voltage-sensitive dye (RH-237) [2].
An optical method using voltage-sensitive dye (RH-237) and a photodiode technique was used for recordings of membrane potential changes with subcellular resolution [3].
Cai transients were mapped optically in isolated arterially perfused swine right ventricles using the fluorescent dye rhod 2 AM while intracellular membrane potential was simultaneously recorded either locally with a microelectrode (5 preparations) or globally with the voltage-sensitive dye RH-237 (5 preparations) [4].
METHODS AND RESULTS: Monolayers of neonatal rat myocytes were stained with fluorescent dye RH-237 (Vm) and Fluo-3AM (Ca(i)2+) [5].

Associations of 4-[4-[(1E,3E,5E)-6-[4-(dibutylamino)phenyl]hexa-1,3,5-trienyl]-1-pyridyl]butane-1-sulfonic acid with other chemical compounds

Dyes RH 160, RH 237, and RH 421 performed excellently as fast fluorescent probes of cardiac membrane potential [6].
Cultures of neonatal rat myocytes were double-stained with dyes RH-237 (Vm) and an analog of Fluo-3 or Rhod-2 dyes (Ca2+) [7].

References

Spatial changes in transmembrane potential during extracellular electrical shocks in cultured monolayers of neonatal rat ventricular myocytes. Gillis, A.M., Fast, V.G., Rohr, S., Kléber, A.G. Circ. Res. (1996) [Pubmed]
Anisotropic conduction in monolayers of neonatal rat heart cells cultured on collagen substrate. Fast, V.G., Kléber, A.G. Circ. Res. (1994) [Pubmed]
Microscopic conduction in cultured strands of neonatal rat heart cells measured with voltage-sensitive dyes. Fast, V.G., Kléber, A.G. Circ. Res. (1993) [Pubmed]
Intracellular Ca dynamics in ventricular fibrillation. Omichi, C., Lamp, S.T., Lin, S.F., Yang, J., Baher, A., Zhou, S., Attin, M., Lee, M.H., Karagueuzian, H.S., Kogan, B., Qu, Z., Garfinkel, A., Chen, P.S., Weiss, J.N. Am. J. Physiol. Heart Circ. Physiol. (2004) [Pubmed]
Simultaneous optical mapping of transmembrane potential and intracellular calcium in myocyte cultures. Fast, V.G., Ideker, R.E. J. Cardiovasc. Electrophysiol. (2000) [Pubmed]
Fluorescent styryl dyes applied as fast optical probes of cardiac action potential. Müller, W., Windisch, H., Tritthart, H.A. Eur. Biophys. J. (1986) [Pubmed]
Simultaneous optical imaging of membrane potential and intracellular calcium. Fast, V.G. Journal of electrocardiology. (2005) [Pubmed]

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