Disease relevance of Styrocide

• Treatment with nitrostyrene at doses >0.75 microg/mL had a significant suppressive effect on the proliferation of stomach cancer lines [1].

High impact information on Styrocide

• Potent inhibition of human telomerase by nitrostyrene derivatives [2].
• Conversion of alcohol 30 to either nitroketone 36 or nitrostyrene 45 set the stage for reductive cyclization and the formation of indole 25 [3].
• The nitrostyrene (NS) moiety was identified as the structure essential for apoptosis induction [4].
• Each of these substances is a typical by-product for at least one of the three approaches most often used to synthesise amphetamine, namely, the Leuckart, the reductive amination of benzyl methyl ketone, and the nitrostyrene routes [5].
• The effect of nitrostyrene on cell proliferation and macrophage immune responses [1].

Biological context of Styrocide

• A one-pot two-step reduction of the substituted 11C-labelled nitrostyrene intermediates, gave after hydrolysis and reversed-phase semi-preparative HPLC-purification the corresponding labelled amines in a total radiochemical yield of 8-20% (based on [11C]CO2 and decay-corrected) [6].
• In the study the effects of nitrostyrene, a reaction by-product in one of the routes to synthesis of amphetamine sulphate, on cell viability and macrophage function was determined [1].

Associations of Styrocide with other chemical compounds

• A nitrostyrene adduct of ascorbic acid proved to be a more potent and effective inhibitor of PP2A as well as a stronger inducer of apoptosis [7].

References