Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AC1LD8HW (2S)-2-[[4-[(2-amino-4-oxo- 4a,7-dihydro-1H...

Synonyms:

Agers??, Y. et al., Nagothu, K.K. et al.

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High impact information on Dihydropteroyl-L-glutamic acid

RESULTS AND CONCLUSIONS: dfrA25 encodes a dihydrofolate reductase of 157 amino acids with closest identity (85%) to dfrA5 dihydrofolate reductase. dfrA25 was located on a transferable plasmid ( approximately 150 kb) that also harboured the tetracycline resistance gene tet(A) [1].
HCT-116 cells were preincubated with or without (control) FA or one of its metabolites (10 microg/ml) for 48 h, transfected with the EGFR promoter luciferase reporter construct, and incubated for 48 h with FA, DF, TF, or 5-MTF in the absence or presence of 10% FBS [2].

References

dfrA25, a novel trimethoprim resistance gene from Salmonella Agona isolated from a human urine sample in Brazil. Agers??, Y., Peirano, G., Aarestrup, F.M. J. Antimicrob. Chemother. (2006) [Pubmed]
Folic acid-mediated inhibition of serum-induced activation of EGFR promoter in colon cancer cells. Nagothu, K.K., Rishi, A.K., Jaszewski, R., Kucuk, O., Majumdar, A.P. Am. J. Physiol. Gastrointest. Liver Physiol. (2004) [Pubmed]

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