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Chemical Compound Review:

AG-G-01844 3-[bis(4- chlorophenyl)methyl]-1-[2- (2,4...

Synonyms: CHEMBL1208858, C3930_SIGMA, CHEBI:782655, CTK8F8430, HMS2230P23, ...

This record was replaced with 2531.

Lis, R. et al., Tyler, R.C. et al., Fowler, C.J. et al., Argentaro, A. et al., Sansom, A.J. et al., et al.

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Disease relevance of Calmidazolium

Injections of calmidazolium chloride into the ipsilateral medial vestibular nucleus or fourth ventricle reduce spontaneous ocular nystagmus following unilateral labyrinthectomy in guinea pigs [1].

High impact information on Calmidazolium

A CaM antagonist, calmidazolium chloride (CDZ), was observed to block CaM recognition of SOX9 in vitro and inhibit both nuclear import and consequent transcriptional activity of SOX9 in treated cells [2].
Novel analogues of the class III antiarrhythmic agent 1-[2-hydroxy-2-[4-[(methylsulfonyl)amino]phenyl]ethyl]-3-methyl-1H- imidazolium chloride, 1 (CK-1649), were prepared and investigated for their class III electrophysiological activity on isolated canine cardiac Purkinje fibers and ventricular muscle tissue [3].
In 100 mM imidazolium chloride (pH 7), the specific activity is 47 mumol of dihydrofolate reduced per min per mg at 30 degrees [4].
A Palladium/imidazolium chloride system has been used to mediate the dimerization of terminal alkynes to enynes [5].
The calmodulin inhibitor calmidazolium chloride inhibited the activity of soluble and particulate Ins(1,4,5)P3-5-phosphatase from GH3 cells, with an IC50 value of approximately 100 microM following a 10-min preincubation with the enzyme [6].

Biological context of Calmidazolium

We report gene transfer to the normal and injured murine pulmonary circulation via systemic (intravascular) and airway (intratracheal) delivery of novel polycationic liposomes (imidazolium chloride, imidazolinium chloride-cholesterol, and ethyl phosphocholine) [7].

References

Injections of calmidazolium chloride into the ipsilateral medial vestibular nucleus or fourth ventricle reduce spontaneous ocular nystagmus following unilateral labyrinthectomy in guinea pigs. Sansom, A.J., Darlington, C.L., Smith, P.F., Gilchrist, D.P., Keenan, C.J., Kenyon, R. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (1993) [Pubmed]
A SOX9 defect of calmodulin-dependent nuclear import in campomelic dysplasia/autosomal sex reversal. Argentaro, A., Sim, H., Kelly, S., Preiss, S., Clayton, A., Jans, D.A., Harley, V.R. J. Biol. Chem. (2003) [Pubmed]
Synthesis and antiarrhythmic activity of novel 3-alkyl-1-[omega-[4-[(alkylsulfonyl)amino]phenyl]-omega- hydroxyalkyl]-1H-imidazolium salts and related compounds. 2. Lis, R., Davey, D.D., Morgan, T.K., Lumma, W.C., Wohl, R.A., Jain, V.K., Wan, C.N., Argentieri, T.M., Sullivan, M.E., Cantor, E.H. J. Med. Chem. (1987) [Pubmed]
Purification and properties of Escherichia coli dihydrofolate reductase. Baccanari, D., Phillips, A., Smith, S., Sinski, D., Burchall, J. Biochemistry (1975) [Pubmed]
Regio- and stereoselective dimerization of terminal alkynes to enynes catalyzed by a palladium/imidazolium system. Yang, C., Nolan, S.P. J. Org. Chem. (2002) [Pubmed]
Time-dependent inhibition of inositol-1,4,5-trisphosphate-5-phosphatase by calmidazolium chloride in rat GH3 cells. Fowler, C.J., Eriksson, A.M. Cell. Signal. (1992) [Pubmed]
Vascular inflammation inhibits gene transfer to the pulmonary circulation in vivo. Tyler, R.C., Fagan, K.A., Unfer, R.C., Gorman, C., McClarrion, M., Bullock, C., Rodman, D.M. Am. J. Physiol. (1999) [Pubmed]

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