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Chemical Compound Review

Rilpivirine     4-[[4-[[4-[(E)-2- cyanoethenyl]-2,6...

Synonyms: Mu O-conotoxin, cc-93, TMC-278, TMC278, CHEMBL175691, ...
 
 
 
 
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High impact information on TMC278

  • Secondary outcomes were evaluation of pharmacokinetics of TMC278, immunologic changes, safety and tolerability, and evolution of viral genotypic and phenotypic patterns [1].
 

Analytical, diagnostic and therapeutic context of TMC278

  • A significantly higher proportion of subjects in the TMC278 groups obtained a viral load decrease of > 1.0 log10 compared with the placebo group (25/36 versus 0/11) (P < 0.01) [1].

References

  1. Short-term antiviral activity of TMC278 - a novel NNRTI - in treatment-naive HIV-1-infected subjects. Goebel, F., Yakovlev, A., Pozniak, A.L., Vinogradova, E., Boogaerts, G., Hoetelmans, R., de Béthune, M.P., Peeters, M., Woodfall, B. AIDS (2006) [Pubmed]
 
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