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Chemical Compound Review: 

AC1O56KG     3-chloro-N-[[4-(2- hydroxyethyl)-4-oxido-2...

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High impact information on Tiaramide N-oxide

  • Reactive oxygen diradicals involved in cytochrome P-450 cycles react with electron rich groups and reactive C-H bonds of zotepine and tiaramide to produce metabolites of 2-hydroxyzotepine, 3-hydroxyzotepine, norzotepine, zotepine-N-oxide, zotepine-S-oxide, Tiaramide carboxylic acid, dehydroxyethyltiaramide and tiaramide-N-oxide [1].

References

  1. Strategy for structure elucidation of drug metabolites derived from protonated molecules and (MS)n fragmentation of zotepine, tiaramide and their metabolites. Tozuka, Z., Kaneko, H., Shiraga, T., Mitani, Y., Kawamura, A., Kagayama, A., Aoba, A. Drug Metab. Pharmacokinet. (2002) [Pubmed]
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