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Chemical Compound Review

Hansolar     N-[4-(4-acetamidophenyl) sulfonylphenyl]eth...

Synonyms: Acetamin, Rodilone, Acedapsone, DADDS, Sulfadiamine, ...
 
 
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Disease relevance of Sulfadiamine

 

High impact information on Sulfadiamine

  • However, acetylation of DDS after DADDS did not differentiate the patients into acetylator phenotypes [3].
  • They were being treated according to a 2-phase monotherapy regimen with RMP first and DADDS afterwards [4].
  • The number of Mycobacterium leprae in the pretreatment biopsy-specimen does not determine the rate of response of patients with lepromatous leprosy to chemotherapy with acedapsone [5].
  • It is advisible to discontinue further injection of DADDS if initial signs of ENL are noticed, which are likely to occur after the second injection [6].
 

Analytical, diagnostic and therapeutic context of Sulfadiamine

References

  1. Susceptibility of Mycobacterium leprae to dapsone as a determinant of patient response to acedapsone. Levy, L., Peters, J.H. Antimicrob. Agents Chemother. (1976) [Pubmed]
  2. Activity and effective serum level of repository sulphones (DADDS) in lepromatous leprosy. Anand, L.C., Rathore, B.S. Leprosy in India. (1979) [Pubmed]
  3. Acedapsone treatment of leprosy patients: response versus drug disposition. Peters, J.H., Murray, J.F., Gordon, G.R., Levy, L., Russell, D.A., Scott, G.C., Vincin, D.R., Shepard, C.C. Am. J. Trop. Med. Hyg. (1977) [Pubmed]
  4. Survey for secondary dapsone and rifampicin resistance in Cuba. González, A.B., Maestre, J.L., Hernández, O., Columbié, Y., Atrio, N., Martin, M., Fernández, A.M., Rodríguez, J. Leprosy review. (1993) [Pubmed]
  5. The number of Mycobacterium leprae in the pretreatment biopsy-specimen does not determine the rate of response of patients with lepromatous leprosy to chemotherapy with acedapsone. Levy, L., Shepard, C.C. Leprosy review. (1986) [Pubmed]
  6. Clinical trial of DADDS in lepromatous leprosy. Ganapati, R., Naik, S.S., Shah, M.H., Shirsat, L.S., Gaitonde, B.B. Leprosy in India. (1976) [Pubmed]
  7. Activation of diacetyldapsone and a preliminary evaluation of a cyclodextrin-diacetyldapsone complex in cultured lung cells. Nimbalkar, D., Birudaraj, R., Jones, P.R., Smith, T.J. Biotechnol. Appl. Biochem. (2001) [Pubmed]
  8. Chemoprophylaxis against leprosy with acedapsone. Neelan, P.N., Noordeen, S.K., Sivaprasad, N. Indian J. Med. Res. (1983) [Pubmed]
 
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