Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

ddATP [[[(2S,5R)-5-(6-aminopurin-9- yl)oxolan-2...

Synonyms: CHEMBL1383, CHEBI:423638, DNC012888, FT-0609592, DB02189, ...

Masood, R. et al., Martinez, C.I. et al.

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High impact information on ATP

This result suggests that AATP could be used as a 2',3'-dideoxyadenosine-5'-triphosphate (ddA) surrogate [1].
At this point, the metabolic pathway diverges, to result in either cleavage and inactivation of 2',3'-ddlno by purine nucleoside phosphorylase or in 5'-phosphorylation by a phosphotransferase, a reaction that generates 2',3'-inosine monophosphate and ultimately the putative active metabolite 2',3'-dideoxy-ATP [2].

References

An allylic/acyclic adenosine nucleoside triphosphate for termination of DNA synthesis by DNA template-dependent polymerases. Martinez, C.I., Thoresen, L.H., Gibbs, R.A., Burgess, K. Nucleic Acids Res. (1999) [Pubmed]
2'-Fluoro-2',3'-dideoxyarabinosyladenine: a metabolically stable analogue of the antiretroviral agent 2',3'-dideoxyadenosine. Masood, R., Ahluwalia, G.S., Cooney, D.A., Fridland, A., Marquez, V.E., Driscoll, J.S., Hao, Z., Mitsuya, H., Perno, C.F., Broder, S. Mol. Pharmacol. (1990) [Pubmed]

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