Disease relevance of Flenac

• Hypothyroidism in patients on fenclofenac [1].
• Nephrotic syndrome and renal impairment associated with fenclofenac [2].
• Biochemical and clinical effects of fenclofenac in thyrotoxicosis [3].
• Twenty eight children (age range 3-17 years) with juvenile rheumatoid arthritis (JRA) received fenclofenac 10-25 mg/kg body weight daily on an open basis [4].
• Fenclofenac-induced selective IgA deficiency in rheumatoid arthritis [5].

High impact information on Flenac

• There was a marked fall in transmucosal potential difference and a decrease in electrical resistance in fenclofenac-treated mucosae whereas indomethacin had less effect on electrical properties at the concentrations used here [6].
• Quantitation of dose and concentration-effect relationships for fenclofenac in rheumatoid arthritis [7].
• To elucidate the mechanism of suppression of TSH responsiveness to TRH induced by the initiation of fenclofenac therapy, the early period of drug administration was examined in detail and the effect of the drug during a thyrotrophin releasing hormone infusion was assessed [8].
• Fenclofenac-secondary effects upon the pituitary thyroid axis [8].
• Assessment of gastric mucosal damage: comparative effects of aspirin and fenclofenac on the gastric mucosa of the guinea pig [9].

Chemical compound and disease context of Flenac

• Administration of the anti-inflammatory drug fenclofenac (600 mg bd) for 28 days to four females with thyrotoxicosis resulted in a rapid decline in thyroid hormone levels [3].
• This case demonstrates the association of selective IgA deficiency with remission in rheumatoid arthritis induced by fenclofenac as well as aurothiomalate and sulphasalazine [5].

Biological context of Flenac

• Pharmacokinetics of fenclofenac in children with juvenile rheumatoid arthritis [4].
• Fenclofenac in the treatment of arthritic conditions: a multi-centre study in general practice [10].

Anatomical context of Flenac

• The effect of fenclofenac on thyroid function [11].
• The effect of fenclofenac on the regeneration of lymphocytes in rats following total body irradiation [12].
• The effect of fenclofenac on the regeneration of white blood cells in Sprague-Dawley rats following total body irradiation was investigated [12].
• Fenclofenac in a dose of 150 mg/kg/day retarded the regeneration of lymphocytes following total body irradiation of 1 Gray: this effect was also seen in the CD4, CD8 and B-lymphocyte subsets [12].
• Our results indicate that ethacrynic acid, meclofenamic acid, fenclofenac, EMD 21388 and diphenylhydantoin affect plasma membrane T3 uptake in the pituitary [13].

Associations of Flenac with other chemical compounds

• The interaction of fenclofenac, and related compounds, while the thyroid hormone binding proteins of serum was studied in vitro by equilibrium dialysis with measurement of the concentrations of the free T4 and T3 in the dialysate by immunoassay [14].
• In nonthyroidal illness, numerous drugs such as glucocorticoids, dopamine, fenclofenac, furosemide and diphenylhydantoin may modify the close inverse-feedback relationship between circulating thyroid hormones and TSH [13].
• A six-month single-blind, randomized parallel group study comparing the effects of fenclofenac and diclofenac in 63 patients with rheumatoid arthritis is described [15].
• In vitro, conventional non-steroidal anti-inflammatory (NSAI) compounds were, with the exception of 10-100 microM hydroxychloroquine, weak (e.g. diclofenac, indomethacin, fenclofenac, effective at concentrations of 100-500 microM), or with some drugs actually ineffective, as inhibitors of CAT-IL-1-mediated PG release [16].
• A double-blind crossover trial of fenclofenac was untertaken to compare the short-term effects of phenylbutazone (Butacote) therapy with fenclofenac therapy (1200 mg daily) in 23 patients suffering from ankylosing spondylitis [17].

Gene context of Flenac

• Both treatments produced a decrease in IgM and the fenclofenac group produced decreases in plasma viscosity and ESR, the latter showing a significant between-treatment effect in favour of fenclofenac [15].

Analytical, diagnostic and therapeutic context of Flenac

• Effect of fenclofenac on thyroid-function tests [18].
• The effect of non-steroidal anti-inflammatory drugs on phytohaemagglutinin stimulated lymphocytes: relevance to possible therapeutic immunosuppression by fenclofenac [19].
• The plasma concentration of the anti-inflammatory drug fenclofenac was investigated in volunteers following single oral doses of 200, 500 and 600 mg, as well as multiple doses of 600mg b.i.d. over five days, using gas chromatography with electron capture detection [20].

References