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Chemical Compound Review:

NSC-8840 diethoxyphosphinic acid

Synonyms: HMDB12209, GEO-01049, NSC-97178, NSC8840, NSC-289195, ...

Knaus, E.E. et al., Avart, S.J. et al., Dulaurent, S. et al., Yang, X.B. et al., Abe, T. et al., et al.

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High impact information on diethoxyphosphinic acid

However, when cells containing isotropic inclusions were incubated with umbelliferyl diethylphosphate, cholesteryl ester hydrolysis was completely inhibited, but chloroquine had no effect [1].
The correlation between theoretical and experimental biotransformation of 2-chloro-1-(2',4' dichlorophenyl) vinyl diethylphosphate (chlorfenvinphos) in the dog and rat [2].
The aim of this study was to develop a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the simultaneous quantitative determination of the following DAP: dimethylphosphate (DMP), dimethythiophosphate (DMTP), dimethyldithiophosphate (DMDTP), diethylphosphate (DEP), diethylthiophosphate (DETP) and diethyldithiophosphate (DEDTP) [3].
5'-O-Trityl-O2,3'-cycloanhydrothymidine (1) heated at 150 degrees C in the presence of O,O-diethyl phosphate or O,O-diethyl phosphorothioate anions undergoes rearrangement into N3-isomer (2); its structure was established by both advanced NMR methods and X-ray crystallographic studies [4].
In experiments with housefly, the value of LD50 for each chemical correlated with the I50 value for acetylcholinesterase except alpha-naphthyl diethylphosphate, beta-naphthyl diethylphosphate and p,p'-biphenyl diethylphosphate [5].

Associations of diethoxyphosphinic acid with other chemical compounds

In cells containing anisotropic inclusions, hydrolysis was partially inhibited by incubation in media containing either chloroquine or umbelliferyl diethylphosphate [1].
A secondary oxidative pathway involved the oxidation of PAR to paraoxon and then hydrolysis to yield p-nitrophenol and diethylphosphoric acid [6].

Analytical, diagnostic and therapeutic context of diethoxyphosphinic acid

The necessity for internal standards; the sensitivity of the HPLC method; and some mass spectral fragmentation pathways for the tau-butyldimethylsily, trimethylsilylacetate, and diethylphosphate derivatives are discussed [7].
The separation, identification, and quantitation of cannabinoids and their tau=butyldimethylsilyl, trimethylsilylacetate, and diethylphosphate derivatives using high-pressure liquid chromatography, gas-liquid chromatography, and mass spectrometry [7].

References

Cholesteryl ester hydrolysis in J774 macrophages occurs in the cytoplasm and lysosomes. Avart, S.J., Bernard, D.W., Jerome, W.G., Glick, J.M. J. Lipid Res. (1999) [Pubmed]
The correlation between theoretical and experimental biotransformation of 2-chloro-1-(2',4' dichlorophenyl) vinyl diethylphosphate (chlorfenvinphos) in the dog and rat. Akintonwa, D.A. J. Theor. Biol. (1985) [Pubmed]
Simultaneous determination of six dialkylphosphates in urine by liquid chromatography tandem mass spectrometry. Dulaurent, S., Saint-Marcoux, F., Marquet, P., Lachâtre, G. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (2006) [Pubmed]
Nucleophilic N1-->N3 rearrangement of 5'-O-trityl-O2,3'-cycloanhydrothymidine. Yang, X.B., Misiura, K., Stec, W.J., Potrzebowski, M.J., Kaźmierski, S., Wieczorek, M., Majzner, W.R., Bujacz, G.D. Nucleosides Nucleotides Nucleic Acids (2000) [Pubmed]
Synthesis of phosphotriester by DCC and its biological activities. Abe, T., Yamada, Y., Shigematsu, Y., Fukami, J., Fujimoto, Y., Tatsuno, T. Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. (1984) [Pubmed]
Pathways of microbial metabolism of parathion. Munnecke, D.M., Hsieh, D.P. Appl. Environ. Microbiol. (1976) [Pubmed]
The separation, identification, and quantitation of cannabinoids and their tau=butyldimethylsilyl, trimethylsilylacetate, and diethylphosphate derivatives using high-pressure liquid chromatography, gas-liquid chromatography, and mass spectrometry. Knaus, E.E., Coutts, R.T., Kazakoff, C.W. Journal of chromatographic science. (1976) [Pubmed]

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