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Chemical Compound Review

AC1LCVHE     1-amino-4-[[4-[[4-chloro-6- [(3...

Synonyms: Affi-gel blue, Basilen Blue, AG-E-84618, CHEMBL1160031, CTK4F8482, ...
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Disease relevance of Reactive Blue 2

  • Reactive Blue 2 improved sensorimotor deficit and restricted the volume of infarction, without preventing the expression of P2X7, but inducing it in the microglia of contralateral frontal and parietal cortex and striatum, which had lost reciprocal connections with the remote infarct area [1].
  • Toxicity studies on Reactive Blue-2 leached from affinity material exposed to extreme chemical conditions [2].
  • Pertussis toxin, suramin, reactive blue 2, PPADS, DPCPX and inhibitors of Protein Kinase C, Protein Kinase A and PI3 kinase significantly reduced the upregulation of egr-1 by exposure to extracellular ATP [3].
  • ATP-induced carotid nerve responses presented no temporal desensitization and persisted after applying P(2Y) receptor blocker Reactive Blue 2 to the ganglion [4].
  • Reactive blue 2, a selective P2Y-purinoceptor antagonist, attenuated dilatations due to ATP and hypoxia [5].

High impact information on Reactive Blue 2


Chemical compound and disease context of Reactive Blue 2


Biological context of Reactive Blue 2


Anatomical context of Reactive Blue 2


Associations of Reactive Blue 2 with other chemical compounds


Gene context of Reactive Blue 2


Analytical, diagnostic and therapeutic context of Reactive Blue 2


  1. P2X7 receptor modulation on microglial cells and reduction of brain infarct caused by middle cerebral artery occlusion in rat. Melani, A., Amadio, S., Gianfriddo, M., Vannucchi, M.G., Volontè, C., Bernardi, G., Pedata, F., Sancesario, G. J. Cereb. Blood Flow Metab. (2006) [Pubmed]
  2. Toxicity studies on Reactive Blue-2 leached from affinity material exposed to extreme chemical conditions. Bertrand, O., Boschetti, E., Cochet, S., Girot, P., Hebert, E., Monsigny, M., Roche, A.C., Santambien, P., Sdiqui, N. Bioseparation (1994) [Pubmed]
  3. Regulation of expression of early growth response transcription factors in rat primary cortical neurons by extracellular ATP. McKee, S.C., Thompson, C.S., Sabourin, L.A., Hakim, A.M. Brain Res. (2006) [Pubmed]
  4. Adenosine triphosphate-induced peripheral nerve discharges generated from the cat petrosal ganglion in vitro. Alcayaga, J., Cerpa, V., Retamal, M., Arroyo, J., Iturriaga, R., Zapata, P. Neurosci. Lett. (2000) [Pubmed]
  5. Adenosine 5'-triphosphate, adenosine and endothelium-derived relaxing factor in hypoxic vasodilatation of the heart. Hopwood, A.M., Lincoln, J., Kirkpatrick, K.A., Burnstock, G. Eur. J. Pharmacol. (1989) [Pubmed]
  6. Identification of the major component of the estrogen-induced protein of rat uterus as the BB isozyme of creatine kinase. Reiss, N.A., Kaye, A.M. J. Biol. Chem. (1981) [Pubmed]
  7. Synaptic P2X7 and oxygen/glucose deprivation in organotypic hippocampal cultures. Cavaliere, F., Amadio, S., Sancesario, G., Bernardi, G., Volonté, C. J. Cereb. Blood Flow Metab. (2004) [Pubmed]
  8. P2 receptor-mediated proliferative effects on astrocytes in vivo. Franke, H., Krügel, U., Illes, P. Glia (1999) [Pubmed]
  9. Evidence for P2-purinoceptor-mediated uptake of Ca2+ across a fish (Oreochromis mossambicus) intestinal brush border membrane. Klaren, P.H., Wendelaar Bonga, S.E., Flik, G. Biochem. J. (1997) [Pubmed]
  10. In vitro toxicity assays for dye ligands used in affinity chromatography. Santambien, P., Sdiqui, S., Hubert, E., Girot, P., Roche, A.C., Monsigny, M., Boschetti, E. J. Chromatogr. B, Biomed. Appl. (1995) [Pubmed]
  11. Extracellular ATP has stimulatory effects on the expression and release of IL-6 via purinergic receptors in normal human epidermal keratinocytes. Inoue, K., Hosoi, J., Denda, M. J. Invest. Dermatol. (2007) [Pubmed]
  12. P2X7 receptors stimulate AKT phosphorylation in astrocytes. Jacques-Silva, M.C., Rodnight, R., Lenz, G., Liao, Z., Kong, Q., Tran, M., Kang, Y., Gonzalez, F.A., Weisman, G.A., Neary, J.T. Br. J. Pharmacol. (2004) [Pubmed]
  13. Effect of shear stress on the release of soluble ecto-enzymes ATPase and 5'-nucleotidase along with endogenous ATP from vascular endothelial cells. Yegutkin, G., Bodin, P., Burnstock, G. Br. J. Pharmacol. (2000) [Pubmed]
  14. The effects of adenosine triphosphate and related purines on arterial resistance vessels in vitro and in vivo. Taylor, E.M., Parsons, M.E., Wright, P.W., Pipkin, M.A., Howson, W. Eur. J. Pharmacol. (1989) [Pubmed]
  15. ATP-stimulated ANP release through P1 receptor subtype. Cao, C., Piao, F.L., Han, J.H., Kim, S.Z., Kim, S.H. Regul. Pept. (2005) [Pubmed]
  16. Characterization and distribution of P2-purinoceptor subtypes in rat pulmonary vessels. Liu, S.F., McCormack, D.G., Evans, T.W., Barnes, P.J. J. Pharmacol. Exp. Ther. (1989) [Pubmed]
  17. P2-purinoceptors of two subtypes in the rabbit mesenteric artery: reactive blue 2 selectively inhibits responses mediated via the P2y-but not the P2x-purinoceptor. Burnstock, G., Warland, J.J. Br. J. Pharmacol. (1987) [Pubmed]
  18. Antagonism by reactive blue 2 but not by brilliant blue G of extracellular ATP-evoked responses in PC12 phaeochromocytoma cells. Inoue, K., Nakazawa, K., Ohara-Imaizumi, M., Obama, T., Fujimori, K., Takanaka, A. Br. J. Pharmacol. (1991) [Pubmed]
  19. Suramin and reactive blue 2 are antagonists for a newly identified purinoceptor on rat megakaryocyte. Uneyama, H., Uneyama, C., Ebihara, S., Akaike, N. Br. J. Pharmacol. (1994) [Pubmed]
  20. Adenosine triphosphate-evoked currents in cultured neurones dissociated from rat parasympathetic cardiac ganglia. Fieber, L.A., Adams, D.J. J. Physiol. (Lond.) (1991) [Pubmed]
  21. Effects of extracellular pH on agonism and antagonism at a recombinant P2X2 receptor. King, B.F., Wildman, S.S., Ziganshina, L.E., Pintor, J., Burnstock, G. Br. J. Pharmacol. (1997) [Pubmed]
  22. Inhibition of NMDA-gated ion channels by the P2 purinoceptor antagonists suramin and reactive blue 2 in mouse hippocampal neurones. Peoples, R.W., Li, C. Br. J. Pharmacol. (1998) [Pubmed]
  23. Long-term potentiation of glutamatergic synaptic transmission induced by activation of presynaptic P2Y receptors in the rat medial habenula nucleus. Price, G.D., Robertson, S.J., Edwards, F.A. Eur. J. Neurosci. (2003) [Pubmed]
  24. Postnatal changes in response to adenosine and adenine nucleotides in rat duodenum. Furukawa, K., Nomoto, T. Br. J. Pharmacol. (1989) [Pubmed]
  25. ATP Stimulates Mouse Embryonic Stem Cell Proliferation via Protein Kinase C, Phosphatidylinositol 3-Kinase/Akt, and Mitogen-Activated Protein Kinase Signaling Pathways. Heo, J.S., Han, H.J. Stem Cells (2006) [Pubmed]
  26. ATP activates P2x-contracting and P2y-relaxing purinoceptors in the smooth muscle of mouse vas deferens. Boland, B., Himpens, B., Vincent, M.F., Gillis, J.M., Casteels, R. Br. J. Pharmacol. (1992) [Pubmed]
  27. An assessment of the antagonistic activity of reactive blue 2 at P1- and P2-purinoceptors: supporting evidence for purinergic innervation of the rabbit portal vein. Reilly, W.M., Saville, V.L., Burnstock, G. Eur. J. Pharmacol. (1987) [Pubmed]
  28. Interaction of 4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase with Reactive Blue 2 and related dyes. Maruyama, K. J. Biochem. (1988) [Pubmed]
  29. Age-related changes in adenosine 5'-triphosphate-induced constriction of isolated, perfused mesenteric arteries of rats. Konishi, C., Naito, Y., Ohara, N. Life Sci. (1999) [Pubmed]
  30. ATP- and adenosine-induced relaxation of the smooth muscle of the pig urethra. Werkström, V., Andersson, K.E. BJU international. (2005) [Pubmed]
  31. Inhibition of purified chicken gizzard smooth muscle ecto-ATPAse by P2 purinoceptor antagonists. Stout, J.G., Kirley, T.L. Biochem. Mol. Biol. Int. (1995) [Pubmed]
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