Disease relevance of Butenone

• Mutagenicity of methylvinyl ketone in Salmonella typhimurium TA100--indication for epoxidation as an activation mechanism [1].
• Upper respiratory tract toxicity of inhaled methylvinyl ketone in F344 rats and B6C3F1 mice [2].

High impact information on Butenone

• The beta-adrenoceptor blocking properties of vaninolol ((+/-)4-[4'-(2-hydroxy-3-tert-butyl-aminopropoxy)-3'-methoxyphenyl]- 3-buten-2-one), derived from vanillin, were first investigated under in vivo and in vitro conditions [3].
• Exposure of synaptosomes to high concentrations of ACR (1M), N-ethylmaleimide (10mM), and methyl vinyl ketone (MVK) (100mM) did not alter the gel migration of synaptosomal proteins [4].
• Biodegradable poly(phosphoesters) with varying side group chemistry and copolymers of styrene and methyl vinyl ketone (MVK) with varying degrees of hydrophobicity were used to study the growth and behavior of surface-attached fibroblasts and hepatocytes [5].
• Quantum yields for acyl (RCO) radical production from ketone photolysis as a function of temperature, pressure and the atmospherically relevant wavelengths (308 and 320 nm) have been determined for methylethyl ketone (MEK), methylvinyl ketone (MVK) and diethyl ketone (DEK) via direct observation of the OH product from the RCO + O2 reaction [6].
• Significant quenching of phosphorescence with a decrease in phosphorescence lifetime was also caused by NaNO2, methylvinyl ketone and trichloroacetate, without effect on ATPase activity; this quenching did not show saturation and was therefore probably collisional in nature [7].

Chemical compound and disease context of Butenone

• Using the Ames Salmonella/microsomal assay, mutagens were detected in acetone-methylene chloride extracts of black threads on glass tube-type sterilization indicators used in hospitals and research laboratories [8].

References