The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

Esuprona     7-ethylsulfonyloxy-3,4- dimethyl-chromen-2-one

Synonyms: Esuprone, Esupronum, CHEMBL18504, CHEBI:121830, AC1L241N, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Esuprone

  • The data thus suggest that selective MAO-A inhibitors such as esuprone may be an interesting new approach for the treatment of epilepsy [1].
 

High impact information on Esuprone

  • In contrast to esuprone and L-deprenyl, the selective MAO-B inhibitor LU 53439 was not effective in the kindling model; this substantiates the previous notion that the anticonvulsant activity of L-deprenyl is not related to MAO-B inhibition, but to other effects of this drug, such as inhibition of MAO-A [1].
  • OBJECTIVE: The aim of the study was to investigate whether or not esuprone binds substantially to MAO-A in the human brain [2].
  • Plasma kinetics of esuprone showed a rapid elimination with a half-life of about 4 h [2].
 

Associations of Esuprone with other chemical compounds

  • CONCLUSION: The study demonstrates that esuprone was comparable to moclobemide in its effect on MAO-A inhibition in the brain at the doses given [2].
 

Analytical, diagnostic and therapeutic context of Esuprone

  • RESULTS: PET showed a high degree of binding of [11C]harmine, a high-affinity ligand for MAO-A, before the start of treatment, and a marked and similar reduction after treatment with esuprone and moclobemide [2].

References

  1. Inhibition of monoamine oxidase type A, but not type B, is an effective means of inducing anticonvulsant activity in the kindling model of epilepsy. Löscher, W., Lehmann, H., Teschendorf, H.J., Traut, M., Gross, G. J. Pharmacol. Exp. Ther. (1999) [Pubmed]
  2. MAO-A inhibition in brain after dosing with esuprone, moclobemide and placebo in healthy volunteers: in vivo studies with positron emission tomography. Bergström, M., Westerberg, G., Németh, G., Traut, M., Gross, G., Greger, G., Müller-Peltzer, H., Safer, A., Eckernäs, S.A., Grahnér, A., Långström, B. Eur. J. Clin. Pharmacol. (1997) [Pubmed]
 
WikiGenes - Universities