Disease relevance of Methacrylic amide

• Combination chemotherapy and photodynamic therapy with N-(2-hydroxypropyl) methacrylamide copolymer-bound anticancer drugs inhibit human ovarian carcinoma heterotransplanted in nude mice [1].
• In this study, we investigated the biorecognizability of specific oligopeptide sequences linking 5-fluorouracil to a water-soluble copolymer carrier based on N-(2-hydroxypropyl) methacrylamide by human cathepsin B (EC 3.4.22.1), cathepsin H(EC 3.4.22.6), and a homogenate of the human colon adenocarcinoma cell line SW 480 [2].
• Both radioactivity in tissues and its recovery in urine in rats, and tissue radioactivity in mice, were lower than in rabbits, when adjusted for dose per unit body weight, suggesting lower skin permeability for methacrylamide in the former species.(ABSTRACT TRUNCATED AT 250 WORDS)[3]
• Drug polymer combinations IV. Toxicity screening of procainamide and its methacrylamide derivates on Artemia [4].

High impact information on Methacrylic amide

• Spinal cords of adult cats were transected and subsequently reconnected with the biocompatible porous poly (N-[2-hydroxypropyl] methacrylamide) hydrogel, NeuroGel [5].
• Structure-activity relationships of water-soluble cationic methacrylate/methacrylamide polymers for nonviral gene delivery [6].
• Almost all studied cationic methacrylate/methacrylamide polymers were able to condense the structure of plasmid DNA, yielding polymer/plasmid complexes (polyplexes) with a size of 0.1-0.3 micron and a slightly positive zeta-potential, which can be taken up by cells, e.g., via endocytosis [6].
• The degradability was provided by hydrolyzable segment between the main PEO chain and the methacrylate or methacrylamide groups at the both PEO chain termini [7].
• Determination of acrylamide and methacrylamide by normal phase high performance liquid chromatography and UV detection [8].

Biological context of Methacrylic amide

• This work investigates the ability of the multivalent reactive copolymer of poly[N-(2-hydroxypropopyl) methacrylamide], pHPMA (MA-GG-ONp) to shield lipoplexes from non-specific protein binding [9].
• Conjugates of insulin with copolymers of N-(2-hydroxypropyl) methacrylamide: effects on smooth muscle cell proliferation [10].
• Dynamic shear oscillation measurements at small strain were used to characterize the viscoelastic properties and related differences in the molecular structure of hydrogels based on gelatin methacrylamide [11].

Anatomical context of Methacrylic amide

• Porous monoliths based on N,N-dimethylacrylamide (DMAA) or methacrylamide (MAA) were prepared inside fused silica capillaries as stationary phases for nano-chromatography [12].
• The adhesion and viability of dissociated neurons of rat cerebral hemispheres onto methacrylate and methacrylamide hydrogels, either unmodified or containing collagen, basement membrane proteins, and glucosamine, were measured in vitro [13].

Associations of Methacrylic amide with other chemical compounds

• The difference in the hydrolytic stability between the methacrylamide and the methacrylate, 2-hydroxyethyl methacrylate, HEMA was then discussed [14].
• The polymers used were synthesized from AMPS (2-acrylamido-2-methyl-1-propanesulfonic acid) and LMAm (lauryl methacrylamide) in different mole ratios (from 100:0 to 60:40) [15].
• Timed-pregnant CD-1 outbred albino Swiss mice received either methacrylamide (MAC; 0, 60, 120, or 180 mg/kg/day) or N,N'-methylenebisacrylamide (BAC; 0, 3, 10, or 30 mg/kg/day) p.o. in distilled water on gestational days (GD) 6 through 17 [16].
• The polymeric NAD derivative prepared by copolymerization with methacrylamide had the highest cofactor activities, and the activities for lactate and yeast alcohol dehydrogenases decreased with an increase in the NAD density of the polymer [17].

Gene context of Methacrylic amide

• Copolymerization reactions of the methacrylamide derivatives with HEMA follow the terminal model with reactivity ratio values, determined by the Tidwell and Mortimer (J. Polym. Sci. A 1965;3:369-378) non-linear least-squares treatment, of r(MAI)=0.38, r(HEMA)=1.69; r(MAK)=0.30, r(HEMA)=0.48; and r(MAEK)=0.66, r(HEMA)=2.85 [18].

Analytical, diagnostic and therapeutic context of Methacrylic amide

• Immobilization of beta-fructofuranosidases from Aspergillus on methacrylamide-based polymeric beads for production of fructooligosaccharides [19].

References