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Chemical Compound Review:

Melarsomina N2-[4-[bis(2- aminoethylsulfanyl) arsanyl]ph...

Synonyms: Melarsomine, Melarsominum, RM-340, CHEMBL1650564, LS-172705, ...

Maksimowich, D.S. et al., Raynaud, J.P., McCall, J.W. et al., Neiffer, D.L. et al., Rawlings, C.A. et al., et al.

Tarello,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Melarsomine

Pulmonary thromboembolism and hypertension after thiacetarsamide vs melarsomine dihydrochloride treatment of Dirofilaria immitis infection in dogs [1].
After preliminary toxicity and efficacy models on experimentally infected dogs, in addition, to the reference posology (2.5 mg of melarsomine (RM 340)/kg twice, 24 h apart by deep IM injection) a more practical program for vet practitioners was suggested (2.2 mg/kg twice, 3 h apart) using modelization of the pharmacokinetic data [2].
There may have been direct pulmonary cellular toxicity of melarsomine dihydrochloride or a severe systemic anaphylactic reaction to antigens released after parasite death [3].

High impact information on Melarsomine

Thiacetarsamide appears to have additional effects on vascular smooth muscle, which may explain why fewer complications are observed in dogs treated with melarsomine [4].
OBJECTIVE: To test the effect of thiacetarsamide and melarsomine on vascular responses in isolated rings of pulmonary artery from heartworm-infected dogs [4].
RESULTS: Norepinephrine-induced constriction was not altered by treatment with either thiacetarsamide or melarsomine [4].
Clinical prophylactic activity of melarsomine dihydrochloride (RM 340) against Dirofilaria immitis in heartworm-naive beagles exposed to natural infection in three southeastern states [5].
Leucocytozoon toddi in falcons from Kuwait: epidemiology, clinical signs and response to melarsomine [6].

Biological context of Melarsomine

Trypanosoma avium incidence, pathogenicity and response to melarsomine in falcons from Kuwait [7].

References

Pulmonary thromboembolism and hypertension after thiacetarsamide vs melarsomine dihydrochloride treatment of Dirofilaria immitis infection in dogs. Rawlings, C.A., Raynaud, J.P., Lewis, R.E., Duncan, J.R. Am. J. Vet. Res. (1993) [Pubmed]
Thiacetarsamide (adulticide) versus melarsomine (RM 340) developed as macrofilaricide (adulticide and larvicide) to cure canine heartworm infection in dogs. Raynaud, J.P. Ann. Rech. Vet. (1992) [Pubmed]
Mortality associated with melarsomine dihydrochloride administration in two North American river otters (Lontra canadensis) and a red panda (Ailurus fulgens fulgens). Neiffer, D.L., Klein, E.C., Calle, P.P., Linn, M., Terrell, S.P., Walker, R.L., Todd, D., Vice, C.C., Marks, S.K. J. Zoo Wildl. Med. (2002) [Pubmed]
Effect of arsenical drugs on in vitro vascular responses of pulmonary artery from heartworm-infected dogs. Maksimowich, D.S., Bell, T.G., Williams, J.F., Kaiser, L. Am. J. Vet. Res. (1997) [Pubmed]
Clinical prophylactic activity of melarsomine dihydrochloride (RM 340) against Dirofilaria immitis in heartworm-naive beagles exposed to natural infection in three southeastern states. McCall, J.W., McTier, T.L., Dzimianski, M.T., Raynaud, J.P., Holmes, R.A. Vet. Parasitol. (1994) [Pubmed]
Leucocytozoon toddi in falcons from Kuwait: epidemiology, clinical signs and response to melarsomine. Tarello, W. Parasite (2006) [Pubmed]
Trypanosoma avium incidence, pathogenicity and response to melarsomine in falcons from Kuwait. Tarello, W. Parasite (2005) [Pubmed]

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