Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Antelmicina 4-amino-1-[5-amino-6-[1-[4- amino-3,5...

Synonyms: Antelmycine, Anthelmycin, Hikizimycin, Antelmycinum, NSC-337588, ...

Lacal, J.C. et al., Vuilhorgne, M. et al., González, A. et al.

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High impact information on L 33876

Structure analysis of the nucleoside disaccharide antibiotic anthelmycin by carbon-13 nuclear magnetic resonance spectroscopy. A structural revision of hikizimycin and its identity with anthelmycin [1].
Several antibiotics including anthelmycin, blasticidin S, destomycin A, gougerotin, hygromycin B and edeine complex, known to powerfully block translation in cell-free systems, did neither inhibit protein synthesis in intact mouse L and 3T6 cells, nor in hamster BHK 21 cells, due to failure to cross the cell plasma membrane [2].
Anthelmycin inhibits protein synthesis on both pro- and eukaryotic ribosomes by preventing the peptide bond-forming reaction [3].

References

Structure analysis of the nucleoside disaccharide antibiotic anthelmycin by carbon-13 nuclear magnetic resonance spectroscopy. A structural revision of hikizimycin and its identity with anthelmycin. Vuilhorgne, M., Ennifar, S., Das, B.C., Paschal, J.W., Nagarajan, R., Hagaman, E.W., Wenkert, E. J. Org. Chem. (1977) [Pubmed]
Antibiotics that specifically block translation in virus-infected cells. Lacal, J.C., Vázquez, D., Fernandez-Sousa, J.M., Carrasco, L. J. Antibiot. (1980) [Pubmed]
Inhibition of translation in bacterial and eukaryotic systems by the antibiotic anthelmycin (hikizimycin). González, A., Vázquez, D., Jiménez, A. Biochim. Biophys. Acta (1979) [Pubmed]

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